摘要
Abstract
Objective:To investigate the value of combined diffusion kurtosis imaging(DKI),free water diffusion tensor imaging(FW-DTI),and mean apparent propagator magnetic resonance imaging(MAP-MRI)in predicting 1p/19q co-deletion in adult diffuse gliomas.Materials and Methods:Clinical,pathological,and imaging features from 72 glioma patients with surgically confirmed pathology were retrospectively analyzed.Patients were categorized into the co-deletion group(n=32)and non-co-deletion group(n=40)based on 1p/19q co-deletion status.Preoperative conventional MRI and q-space diffusion spectrum imaging(DSI)were performed,with post-processing generating DKI,FW-DTI,and MAP-MRI parameter maps.Clinical characteristics,conventional MRI features,and differences in diffusion model parameters were compared between groups.Receiver operating characteristic(ROC)curves were utilized to evaluate the predictive value of each parameter for 1p/19q co-deletion in gliomas,with area under curve(AUC)values calculated.Results:Among MRI features,tumor margin indistinctness differed significantly between groups,while other clinical characteristics and MRI features showed no statistically differences.The 1p/19q-deleted group exhibited higher mean kurtosis(MK),extracellular free water fraction(FWF),extracellular water molecule retum-to-origin probability(RTOP),and non-Gaussian index(NG)values compared to the non-deleted group(t-values were 4.913,4.376,3.761,and 6.916,respectively,with P＜0.05.).Conversely,the free water-corrected anisotropy fraction(FW-FA)and q-space inverse variance(QIV)values were lower in the deleted group(t-values were 2.945 and 3.761,with P＜0.05).No statistically significant differences were observed in other parameters(P＞0.05).The combined AUC value for predicting 1p/19q co-deletion using MK,FWF,and NG was 0.935,with a sensitivity of 85.00％and specificity of 93.75％.Conclusions:The combination of DKI,FW-DTI,and MAP-MRI can predict the status of 1p/19q co-deletion in gliomas preoperatively,facilitating the development of individualized treatment plans.关键词
胶质瘤/1p/19q共缺失/磁共振成像/扩散峰度成像/自由水扩散张量成像/平均表观传播子Key words
glioma/1p/19q co-deletion/magnetic resonance imaging/diffusion kurtosis imaging/free water diffusion tensor imaging/mean apparent propagator分类
医药卫生
