陆军军医大学学报2026，Vol.48Issue(9)：1282-1288,封3,8.DOI:10.16016/j.2097-0927.202601039
主观认知下降对老年代谢综合征患者衰弱的影响:体力活动与抑郁的平行中介作用
Impact of subjective cognitive decline on frailty in elderly patients with metabolic syndrome:the parallel mediating effects of physical activity and depression
摘要
Abstract
Objective Elderly patients with metabolic syndrome often present with concurrent subjective cognitive decline and frailty,yet the underlying mechanisms linking these conditions remain unclear.This study aims to explore the parallel mediating effects of physical activity levels and depression on the relationship between subjective cognitive decline and frailty in elderly patients with metabolic syndrome,identify potential pathways and key factors through which subjective cognitive decline influences frailty,and provide evidence to support the development of intervention strategies.Methods A cross-sectional study was conducted on 348 hospitalized elderly patients with metabolic syndrome admitted to 10 internal medicine departments(including Respiratory Medicine,Neurology,Hypertension and Endocrinology,and Cardiology)in Daping Hospital of Army Medical University from June to December 2024.Subjective cognitive decline was assessed using the Subjective Cognitive Decline Questionnaire(SCD-Q9),depression using the Center for Epidemiologic Studies Depression Scale 10(CES-D 10),frailty using the Fatigue,Resistance,Ambulation,Illnesses,and Loss of Weight(FRAIL)Scale,and physical activity levels using the International Physical Activity Questionnaire Short Form(IPAQ-SF).Pearson correlation analysis was performed to assess the correlation coefficients between frailty,subjective cognitive decline,depression,and physical activity levels.The Process macro in SPSS 27.0 was used to construct the mediation effect model.Results Subjective cognitive decline was positively correlated with depression(r=0.210,P<0.001)and frailty(r=0.275,P<0.001),and negatively correlated with physical activity levels(r=-0.199,P<0.001).Physical activity levels were negatively correlated with frailty(r=-0.228,P<0.001),and frailty was positively correlated with depression(r=0.251,P<0.001).Physical activity levels and depression exerted parallel mediating effects between subjective cognitive decline and frailty,with effect values of 0.009(95%CI:0.003 to 0.017)and 0.012(95%CI:0.004 to 0.021),accounting for 12.50%and 16.67%of the total effect,respectively.Conclusion Physical activity levels and depression play parallel mediating roles between subjective cognitive decline and frailty in elderly patients with metabolic syndrome.Clinicians should emphasize screening for subjective cognitive decline in these patients.And interventions aimed at enhancing physical activity and targeting depressive symptoms may help delay frailty progression and improve quality of life.关键词
老年代谢综合征/衰弱/抑郁/主观认知下降/体力活动水平Key words
geriatric metabolic syndrome/frailty/depression/subjective cognitive decline/physical activity level分类
医药卫生引用本文复制引用
吴诺一,徐元春,吴银雨,曹薇,刘娟,王亚玲..主观认知下降对老年代谢综合征患者衰弱的影响:体力活动与抑郁的平行中介作用[J].陆军军医大学学报,2026,48(9):1282-1288,封3,8.基金项目
陆军特色医学中心人才创新能力培养计划(ZXYZZKY06) Supported by the Training Plan for Talent Innovation Capacity of Army Medical Center of PLA(ZXYZZKY06). （ZXYZZKY06）
