动物医学进展2026，Vol.47Issue(5)：133-138,6.
重离子辐照技术在生物医药领域的研究及应用
Research and Applications of Heavy Ion Irradiation in Biomedicine
摘要
Abstract
Heavy ion irradiation technology is transitioning from an advanced modality for tumor radiothera-py to a comprehensive platform for biomedical research and development.Its core principle leverages the precise energy deposition of the Bragg peak and complex DNA damage mechanism induced by high linear energy transfer,enabling efficient and accurate modulation of biological targets.In the medical field,it has demonstrated significantefficacy in treating refractory tumors,FLASH ultra-high dose rate radiotherapy,and radiotherapycombined with immunotherapy.In biomanufacturing and virology,its high linear energy transfer characteristics make it a key tool for vaccine inactivation,screening of virus-host interactions,and improvement of industrial microbial strains.Despite its promise,widespread application faces challenges such as high equipment costs and lack of operational standardization.Future development focuses on accelerator miniaturization,optimization aided by artificial intelligence,and convergence with synthetic biology.This review systematically summarizes the physical and biological mechanisms of heavy ion technology,its application prospects in biomedicine,and its industrial potential in an interdisciplinary context.关键词
重离子技术/分子间库仑衰变/疫苗/生物医药/诱变育种Key words
Heavy ion technology/Intermolecular coulombic decay/Vaccines/Biomedicine/Mutation breeding分类
农业科技引用本文复制引用
陶世宇,赵鹏飞,任建明,张兰,董艳娇,李彪,蒋剑成,马雄,胡永浩..重离子辐照技术在生物医药领域的研究及应用[J].动物医学进展,2026,47(5):133-138,6.基金项目
甘肃省青年科技基金项目(24JRRP006) （24JRRP006）
甘肃省高校产业支撑计划项目(2024CYZC-59) （2024CYZC-59）
甘肃民族师范学院高层次人才引进启动项目(2025GCC-12) （2025GCC-12）
