分子影像学杂志2026，Vol.49Issue(4)：515-521,7.DOI:10.12122/j.issn.1674-4500.2026.04.14
肺部混合磨玻璃结节实性成分的CT参数对肺腺癌浸润程度的预测价值
Predictive value of CT parameters of solid components in pulmonary mixed ground-glass nodules for infiltration degree of lung adenocarcinoma
摘要
Abstract
Objective To explore the predictive value of CT parameters of solid components in pulmonary mixed ground-glass nodules(mGGN)for infiltration degree of lung adenocarcinoma.Methods The clinical data of 120 patients with lung adenocarcinoma who presented with pulmonary mGGN and were confirmed by pathology from January 2022 to April 2024 were collected.Based on pathological results,patients with invasive adenocarcinoma(IAC)were included in the IAC group(n=73)and those with adenocarcinoma in situ and minimally invasive adenocarcinoma were included in the non-IAC group(n=47).Baseline data,CT signs and parameters of solid components in mGGN were compared between the two groups.ROC curves were used to evaluate the predictive value of CT parameters of solid components in pulmonary mGGN for IAC.Results Compared with the non-IAC group,the IAC group showed older age,higher proportions of lobulation,spiculation and air bronchogram signs,larger maximum diameter,average diameter,maximum CT value and average CT value of solid components(P<0.05).Multivariate logistic regression analysis showed that lobulation sign,air bronchogram sign,average diameter,maximum CT value,and average CT value were independent influencing factors for infiltration degree of lung adenocarcinoma(P<0.05).ROC curves showed that the optimal cutoff values of average diameter,maximum CT value,and average CT value of solid components in pulmonary mGGN for predicting infiltration degree of lung adenocarcinoma were 10.09 mm,-114.00 HU,and-394.07 HU,respectively.The AUC and sensitivity of combination of these three parameters for predicting infiltration degree of lung adenocarcinoma were 0.892 and 89.04％,respectively.Both were higher than those of any parameter alone(P<0.05).Conclusion CT parameters of solid components in pulmonary mGGN are closely related to infiltration degree of lung adenocarcinoma.Among them,the combination of average diameter,maximum CT value,and average CT value demonstrates high predictive value for infiltration degree of lung adenocarcinoma.关键词
混合磨玻璃结节/实性成分/CT参数/肺腺癌/浸润程度Key words
mixed ground-glass nodule/solid component/CT parameters/lung adenocarcinoma/infiltration degree引用本文复制引用
朱冉冉,孙家龙,吴宗山,黄道余,武前枝..肺部混合磨玻璃结节实性成分的CT参数对肺腺癌浸润程度的预测价值[J].分子影像学杂志,2026,49(4):515-521,7.基金项目
六安市科技局项目(2022lakj019) （2022lakj019）
