分子影像学杂志2026，Vol.49Issue(4)：417-425,9.DOI:10.12122/j.issn.1674-4500.2026.04.01
血压变异性对非衰弱及衰弱前期人群脑结构及认知功能的相关性:基于UK Biobank数据库的MRI联合临床指标分析
Association of blood pressure variability with brain structure and cognitive function in non-frail and pre-frail populations:analysis of MRI combined with clinical indicators based on the UK Biobank
摘要
Abstract
Objective To investigate the impact of visit-to-visit systolic blood pressure variability(SBPV)on brain structure and cognitive function among non-frail and pre-frail populations using data from the UK Biobank database.Methods Clinical and neuroimaging data from 59 087 non-frail and pre-frail individuals at baseline were retrospectively collected from the UK Biobank.SBPV was quantified by calculating the standard deviation(SD)of systolic blood pressure measurements across three visits.Based on SBPV tertiles,participants were categorized into three groups:the T1 group(low SBPV,n=5242),the T2 group(moderate SBPV,n=13 949),and the T3 group(high SBPV,n=39 896).Quantitative brain structural metrics were extracted via MRI,and cognitive function was evaluated using standardized assessments.Multivariable regression models were constructed to analyze the associations of SBPV with MRI-derived brain structural features and cognitive function,while restricted cubic splines(RCS)were applied to explore potential non-linear relationships.Results Multivariable regression analysis revealed that,after adjusting for confounding factors,elevated SBPV was significantly associated with degenerative changes in brain structure.Compared with the low SBPV group,the high SBPV group exhibited a significant reduction in total brain volume(β=-8697.41,95％CI:-10496.65--6898.17,P<0.001)and a significant increase in white matter hyperintensity(WMH)volume(β=600.09,95％CI:466.48-733.69,P<0.001).RCS analysis demonstrated an inverted U-shaped relationship between SBPV and brain volume metrics,and a J-shaped relationship with WMH volume.Furthermore,cognitive function analysis indicated that SBPV exerted complex non-linear effects on specific cognitive domains,including prospective memory and reaction time.Conclusion Among non-frail and pre-frail populations,elevated visit-to-visit SBPV is closely associated with brain structural degeneration and partial cognitive decline.These findings provide objective evidence that maintaining long-term blood pressure stability may serve as a potential interventional target for early neuroprotection.关键词
血压变异性/脑结构/认知功能/衰弱前期Key words
blood pressure variability/brain structure/cognitive function/pre-frailty引用本文复制引用
杨珺淇,许哲浩,梁建文..血压变异性对非衰弱及衰弱前期人群脑结构及认知功能的相关性:基于UK Biobank数据库的MRI联合临床指标分析[J].分子影像学杂志,2026,49(4):417-425,9.基金项目
国家自然科学基金(82170427) （82170427）
广东省基础与应用基础研究基金(2024A1515013213) （2024A1515013213）
深圳市福田区卫生健康系统科研项目(FTWS2023017)Supported by National Natural Science Foundation of China(82170427). （FTWS2023017）
