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Porphyromonas gingivalis-derived extracellular vesicles aggravate bone destruction in rheumatoid arthritis by promoting Syk-dependent osteoclastogenesis

Jiajie Guo Kaya Yoshida Hongchen Sun Lihong Qiu Qiujing Qiu Xiaoyuan Yan Zeying Zhang Xiyue Zhang Na An Chengcheng Yin Di Yang Hirohiko Okamura

国际口腔科学杂志（英文版）2026，Vol.18Issue(2)：258-274,17.

国际口腔科学杂志（英文版）2026，Vol.18Issue(2)：258-274,17.DOI:10.1038/s41368-025-00416-1

Porphyromonas gingivalis-derived extracellular vesicles aggravate bone destruction in rheumatoid arthritis by promoting Syk-dependent osteoclastogenesis

Jiajie Guo ¹Kaya Yoshida ²Hongchen Sun ³Lihong Qiu ¹Qiujing Qiu ¹Xiaoyuan Yan ¹Zeying Zhang ¹Xiyue Zhang ¹Na An ⁴Chengcheng Yin ⁵Di Yang ¹Hirohiko Okamura⁶

作者信息

1. Department of Endodontics,School and Hospital of Stomatology,China Medical University,Liaoning Provincial Key Laboratory of Oral Diseases,Shenyang,China
2. Department of Oral Healthcare Education,Institute of Biomedical Sciences,Tokushima University Graduate School,Tokushima,Japan
3. Department of Oral Pathology,School and Hospital of Stomatology,China Medical University,Liaoning Provincial Key Laboratory of Oral Diseases,Shenyang,China
4. Department of Orthodontics,School and Hospital of Stomatology,China Medical University,Liaoning Provincial Key Laboratory of Oral Diseases,Shenyang,China
5. School and Hospital of Stomatology,Jilin University,Changchun,China||Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling,Changchun,China
6. Department of Oral Morphology,Graduate School of Medicine,Dentistry and Pharmaceutical Sciences,Okayama University,Okayama,Japan
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摘要

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Jiajie Guo,Kaya Yoshida,Hongchen Sun,Lihong Qiu,Qiujing Qiu,Xiaoyuan Yan,Zeying Zhang,Xiyue Zhang,Na An,Chengcheng Yin,Di Yang,Hirohiko Okamura..Porphyromonas gingivalis-derived extracellular vesicles aggravate bone destruction in rheumatoid arthritis by promoting Syk-dependent osteoclastogenesis[J].国际口腔科学杂志（英文版）,2026,18(2):258-274,17.

基金项目

This work was supported by the China Postdoctoral Science Foundation(2021MD703905),National Natural Science Foundation of China(81900992,81870752,82470970),and Natural Science Foundation of Liaoning Province(2023-BS-097).Figure 3a was created in BioRender.Guo,J.(2025)https://BioRender.com/vu8p4uq.Figure 5a was created in BioRender.Guo,J.(2025)https://BioRender.com/c41e720.Figure 8a was created in BioRender.Guo,J.(2025)https://BioRender.com/t45u769.Figure 13 was created in BioRender.Guo,J.(2025)https://BioRender.com/c79a269. （2021MD703905）

国际口腔科学杂志（英文版）

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