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Defining subcellular synovial responses in TMJ osteoarthritis onset via mechanical stress and articular disk derangement models

Kazuhiro Shibusaka Hiroyuki Okada Fumiko Yano Soichiro Negishi Asuka Terashima Miki Maemura Hiroshi Yoshida Masahiro Hosonuma Nobuhiro Sakai Young Kwan Kim Yutaka Suzuki

国际口腔科学杂志（英文版）2026，Vol.18Issue(2)：275-292,18.

国际口腔科学杂志（英文版）2026，Vol.18Issue(2)：275-292,18.DOI:10.1038/s41368-025-00411-6

Defining subcellular synovial responses in TMJ osteoarthritis onset via mechanical stress and articular disk derangement models

Kazuhiro Shibusaka ¹Hiroyuki Okada ²Fumiko Yano ³Soichiro Negishi ⁴Asuka Terashima ⁵Miki Maemura ⁴Hiroshi Yoshida ⁶Masahiro Hosonuma ⁷Nobuhiro Sakai ⁸Young Kwan Kim ⁹Yutaka Suzuki¹⁰

作者信息

1. Department of Biochemistry,Graduate School of Dentistry,Showa Medical University,Shinagawa-ku,Tokyo,Japan||Department of Orthodontics,Graduate School of Dentistry,Showa Medical University,Ota-ku,Tokyo,Japan
2. Center for Disease Biology and Integrative Medicine,Graduate School of Medicine,The University of Tokyo,Bunkyo-ku,Tokyo,Japan
3. Department of Biochemistry,Graduate School of Dentistry,Showa Medical University,Shinagawa-ku,Tokyo,Japan||Showa Medical University Research Administration Center,Showa Medical University,Shinagawa-ku,Tokyo,Japan
4. Department of Biochemistry,Graduate School of Dentistry,Showa Medical University,Shinagawa-ku,Tokyo,Japan||Department of Oral and Maxillofacial Surgery,Graduate School of Dentistry,Showa Medical University,Ota-ku,Tokyo,Japan
5. Bone and Cartilage Regenerative Medicine,The University of Tokyo Hospital,Bunkyo-ku,Tokyo,Japan
6. Department of Orthodontics,Graduate School of Dentistry,Showa Medical University,Ota-ku,Tokyo,Japan
7. Department of Pharmacology,Graduate School of Pharmacy,Showa Medical University,ai,Shinagawa-ku,Tokyo,Japan
8. Division of Dental Education,School of Dentistry,Showa Medical University,Shinagawa-ku,Tokyo,Japan
9. Department of Biosystems Science,Institute for Life and Medical Sciences,Kyoto University,Kyoto,Japan
10. Department of Computational Biology and Medical Sciences,Graduate School of Frontier Sciences,The University of Tokyo,Kashiwa-shi,Chiba,Japan
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摘要

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Kazuhiro Shibusaka,Hiroyuki Okada,Fumiko Yano,Soichiro Negishi,Asuka Terashima,Miki Maemura,Hiroshi Yoshida,Masahiro Hosonuma,Nobuhiro Sakai,Young Kwan Kim,Yutaka Suzuki..Defining subcellular synovial responses in TMJ osteoarthritis onset via mechanical stress and articular disk derangement models[J].国际口腔科学杂志（英文版）,2026,18(2):275-292,18.

基金项目

This work was supported by JSPS KAKENHI Grant Numbers 23K27796(to F.Y.),21KK0155(to F.Y.),and JP22H04925(PAGS)(to Y.S.and F.Y.) （to F.Y.）

The Nakatomi Foundation(to K.S.) （to K.S.）

Young Investigator Award from the American Society for Bone and Mineral Research(to K.S.).We thank Platform for Advanced Genome Science,JP22H04925(PAGS)for the Xenium and Visium HD analysis,and R.Nakano,H.Matsuyama,A.Kanai,K.Abe,E.Sekimori,K.Imamura,J.Sugita,M.Ishihara,R.Homma,and the animal experimentation facility at Showa Medical University for technical assistance.We would also like to thank Editage for English language editing. （to K.S.）

国际口腔科学杂志（英文版）

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