国际妇产科学杂志2026，Vol.53Issue(2)：153-158,6.DOI:10.12280/gjfckx.20251470
B族维生素稳态与妊娠期糖尿病的相关性
Association between B-Vitamin Homeostasis and Gestational Diabetes Mellitus
摘要
Abstract
The homeostasis of B-vitamin is crucial for normal fetal development and maternal health.Studies have found that appropriate supplementation of B-vitamin may contribute to the prevention and management of gestational diabetes mellitus(GDM).GDM is one of the most common metabolic diseases during pregnancy and can exert short-term or long-term adverse effects on the health of both the patient and her offspring.Through a systematic review of relevant domestic and international research,this article explores the association between B-vitamin and GDM,aiming to provide evidence for the scientific supplementation of B-vitamin in clinical practice.Folate(vitamin B9)is an essential micronutrient for one-carbon metabolism.Recent studies have found that serum or erythrocyte folate levels are positively correlated with the risk of GDM,and the risk of developing GDM increases significantly when folate supplement intake exceeds recommended levels.Vitamin B12 is closely related to folate,and an imbalance in their ratio may also be a risk factor of GDM.Vitamins B1,B2,B3,and B6,as key coenzymes or regulators of energy metabolism,also exhibit varying degrees of association between their intake levels and the risk of GDM.An imbalance in B-vitamin nutritional status during pregnancy may increase the risk of GDM,suggesting that appropriate doses of these micronutrients should be supplemented during pregnancy to safeguard maternal and child health.关键词
复合维生素B/糖尿病,妊娠/胰岛素抵抗/葡萄糖代谢障碍/B族维生素稳态Key words
Vitamin B complex/Diabetes,gestational/Insulin resistance/Glucose metabolism disorders/B-vitamin homeostasis引用本文复制引用
沈成璐,胡文胜..B族维生素稳态与妊娠期糖尿病的相关性[J].国际妇产科学杂志,2026,53(2):153-158,6.基金项目
国家自然科学基金(82173530) （82173530）
