国际妇产科学杂志2026，Vol.53Issue(2)：159-164,6.DOI:10.12280/gjfckx.20251278
复发性流产合并遗传性易栓症的中西医研究与治疗进展
Research and Therapeutic Advances in Recurrent Spontaneous Abortion Complicated with Hereditary Thrombophilia
摘要
Abstract
Recurrent spontaneous abortion(RSA)combined with hereditary thrombophilia is a significant cause of adverse pregnancy outcomes.Hereditary thrombophilia mainly involves deficiencies of anticoagulant proteins(protein C,protein S,antithrombin Ⅲ),factor Ⅴ Leiden(FⅤL)mutation,prothrombin G20210A gene mutation(PGM),methylenetetrahydrofolate reductase(MTHFR)gene polymorphisms,and plasminogen activator inhibitor-1(PAI-1)5G/4G gene mutations.Western medical treatment primarily employs low molecular weight heparin(LMWH)anticoagulation to improve hypercoagulability and promote placental blood perfusion,thereby reducing abortion risk.However,there is currently a lack of high-quality evidence-based medical data supporting its efficacy,and its clinical application remains controversial.Traditional Chinese Medicine(TCM)follows the pathogenesis of"kidney deficiency and blood stagnation",adopting the therapeutic principle of"tonifying kidney and activating blood circulation".Under holistic syndrome differentiation,TCM seeks etiological treatment,using classic formulas such as Shoutai Pill to tonify kidney and stabilize the Chong Mai,combined with low-dose promoting blood circulation and removing blood stasis drugs like Salvia miltiorrhiza and Angelica sinensis.Clinical practice has demonstrated considerable efficacy.In recent years,integrated Chinese-Western medicine therapy has shown favorable synergistic effects,improving pregnancy success rate while reducing the dosage and adverse effects of Western medications,thereby providing novel therapeutic strategies for RSA complicated with hereditary thrombophilia.关键词
流产,习惯性/遗传性易栓症/多态现象,遗传/肝素,低分子量/肾虚血瘀/补肾活血Key words
Abortion,habitual/Hereditary thrombophilia/Polymorphism,genetic/Heparin,low-molecular-weight/Kidney deficiency and blood stagnation/Tonifying kidney and activating blood circulation引用本文复制引用
王成霞,赵佳润,郑舒畅,王一迪,何军琴..复发性流产合并遗传性易栓症的中西医研究与治疗进展[J].国际妇产科学杂志,2026,53(2):159-164,6.基金项目
首都卫生发展科研专项(首发2024-2-2114) （首发2024-2-2114）
