广西师范大学学报（自然科学版）2026，Vol.44Issue(3)：204-213,10.DOI:10.16088/j.issn.1001-6600.2025062001
圆锥茎阿魏乙酸乙酯部位化学成分及葡萄糖摄取活性检测
Chemical Components and Glucose Uptake Activity From Ethyl Acetate Fraction of Ferula conocaula Korovin
摘要
Abstract
Using a combination of multiple column chromatography and high-performance liquid chromatography separation techniques,the ethyl acetate fraction of Ferula conocaula Korovin was isolated and purified.Modern spectroscopic methods were employed to structurally characterize the obtained monomeric compounds.This study successfully isolated 19 monomeric compounds from the ethyl acetate fraction of Ferula conocaula Korovin.including 4 polyphenolic monomers,14 caffeoylquinic acid monomers,and 1 flavonoid monomer.They are identified as caffeic acid(1),caffeic acid methyl ester(2),3,4-dihydroxybenzaldehyde(3),5-O-caffeoylquinic acid(4),1-O-caffeoylquinic acid(5),chlorgenic acid(6),methyl chlorogenate(7),3-O-trans-feruloylquinic acid(8),methyl 5-O-p-coumaroylquinic acid(9),methyl 5-O-feruloylquinate(10),acanthopacid G(11),1-(3,4-dihydroxycinnamoyl)cyclopentene-2,3-diol(12),4,5-di-O-caffeoylquinic acid 1-methyl ether(13),4-O-caffeoyl-5-O-feruloylquinic acid methyl ester(14),methy 3,5-dicaffeoylquinate(15),1,5-di-O-caffeoylquinic acid(16),1,3-di-O-caffeoylquinic acid(17),methyl 4-O-E-feruloyl 5-O-E-caffeoyl-quinate(18),and luteolin 7-O-glucoside(19).It is worth nothing that compounds 1-6 and 8-19 were isolated from this plant for the first time.Glucose uptake activity assay experiments showed that compounds 7,13,15,and 16 had strong blood glucose lowering effects.关键词
圆锥茎阿魏/化学成分/咖啡酰奎宁酸/多酚/葡萄糖摄取活性/检测Key words
Ferula conocaula Korovin/chemical composition/caffeoylquinic acid/polyphenol/glucose uptake activity/detect分类
医药卫生引用本文复制引用
廖司仪,楚沫延,庞克坚,卢汝梅,阿吉尔古丽·麦麦提,林亲雄,杨新洲..圆锥茎阿魏乙酸乙酯部位化学成分及葡萄糖摄取活性检测[J].广西师范大学学报（自然科学版）,2026,44(3):204-213,10.基金项目
国家自然科学基金面上项目(82374144) （82374144）
新疆"天池英才"引进计划高校特聘教授项目 （）
