国际妇产科学杂志2026，Vol.53Issue(2)：194-199,6.DOI:10.12280/gjfckx.20251119
中心体蛋白2通过调控DNA损伤修复促进上皮性卵巢癌铂类耐药的研究进展与展望
Research Progress and Perspectives of Centrin 2 in Promoting Platinum Resistance in Epithelial Ovarian Cancer through Regulation of DNA Damage Repair
摘要
Abstract
Epithelial ovarian cancer(EOC)is a lethal malignancy whose treatment failure and recurrence are mainly attributed to platinum-based chemotherapy resistance.Centrin 2(CETN2),a highly conserved centrosome-associated protein and DNA repair protein,has been implicated in platinum resistance in EOC.This review systematically outlines the structural and functional features of CETN2,focusing on its pivotal role in the nucleotide excision repair(NER)pathway,which serves as the key mechanism for removing platinum-induced DNA crosslink damage.CETN2 may drive platinum resistance through multiple mechanisms,including stabilizing the NER damage recognition complex(XPC complex)to enhance DNA damage repair efficiency,disrupting centrosome homeostasis to affect genomic stability,and regulating cell-cycle checkpoints,thereby conferring a survival advantage to EOC cells under genotoxic stress.Furthermore,the critical interaction between CETN2 and XPC protein provides a potential target for developing small-molecule inhibitors,which may not only directly reverse platinum resistance but also synergize with poly(ADP-ribose)polymerase(PARP)inhibitors,offering new combinatorial therapeutic strategies for EOC patients with intact homologous recombination repair function.However,current evidence relies heavily on bioinformatic analyses and clinical correlation studies,with a lack of functional experimental validation.Future research should focus on in-depth molecular mechanism elucidation and targeted intervention strategies to clarify the clinical translational potential of CETN2 as a reversal target for platinum resistance in EOC.关键词
卵巢上皮癌/铂化合物/抗药性,肿瘤/DNA修复/中心体蛋白2Key words
Carcinoma,ovarian epithelial/Platinum compounds/Drug resistance,neoplasm/DNA Repair/Centrin 2引用本文复制引用
韦林媛,潘忠勉,李力..中心体蛋白2通过调控DNA损伤修复促进上皮性卵巢癌铂类耐药的研究进展与展望[J].国际妇产科学杂志,2026,53(2):194-199,6.基金项目
广西科技重点实验室项目(GKE-ZZ202406) （GKE-ZZ202406）
