国际妇产科学杂志2026，Vol.53Issue(2)：200-205,6.DOI:10.12280/gjfckx.20251276
生殖道微生物组在宫颈癌中的研究进展
Research Progress on the Reproductive Tract Microbiome in Cervical Cancer
摘要
Abstract
Persistent infection with high-risk human papilloma virus(HPV)is the key prerequisite for cervical carcinogenesis.However,most infections are cleared by the host immunity system,indicating that additional factors collaborate to drive the oncogenic process.The reproductive tract microbiome primarily inhabits the vaginal and cervical mucosa,where it maintains microenvironmental homeostasis and resists pathogen invasion through mechanisms such as metabolite production and competitive exclusion.Studies indicate that throughout the disease progression from simple HPV infection to cervical intraepithelial neoplasia(CIN)and ultimately to invasive cervical cancer,the reproductive tract microbiome undergoes dynamic remodeling,characterized by Lactobacillus depletion and a significant increase in anaerobic diversity.This dysbiosis not only disrupts the cervical-vaginal mucosal barrier to facilitate HPV integration,but also promotes malignant transformation by inducing persistent chronic inflammation and releasing specific metabolites.Therefore,microbiome-based intervention strategies hold translational promise for blocking HPV infection progression,aiding cervical cancer diagnosis,and enhancing the efficacy while reducing the toxicity of chemoradiotherapy.关键词
宫颈肿瘤/癌/阴道/子宫颈/生殖道/微生物群/乳头状瘤病毒科Key words
Uterine cervical neoplasms/Carcinoma/Vagina/Cervix uteri/Reproductive tract/Microbiota/Papillomaviridae引用本文复制引用
王冰燕,李凤虎..生殖道微生物组在宫颈癌中的研究进展[J].国际妇产科学杂志,2026,53(2):200-205,6.基金项目
贵州省中医药管理局中医药、民族医药科学技术研究课题(QZYY-2025-058) （QZYY-2025-058）
贵州医科大学"先锋计划"科研联合基金项目(XFJHMS202504) （XFJHMS202504）
