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Factor Ⅷ restores bone parameters and modulates muscle proteo-metabolome in Factor Ⅷ knockout male mice

Antoine Babuty Oleksandr Boychenko Marie-Françoise Heymann Dominique Heymann Javier Muñoz-Garcia Olivier D.Christophe Laurie Fradet Manon Taupin Denis Cochonneau Emilie Ollivier Frank Driessler Claudia Lange

骨研究（英文版）2026，Vol.14Issue(2)：507-523,17.

骨研究（英文版）2026，Vol.14Issue(2)：507-523,17.DOI:10.1038/s41413-025-00485-2

Factor Ⅷ restores bone parameters and modulates muscle proteo-metabolome in Factor Ⅷ knockout male mice

Antoine Babuty ¹Oleksandr Boychenko ²Marie-Françoise Heymann ³Dominique Heymann ⁴Javier Muñoz-Garcia ⁵Olivier D.Christophe ⁶Laurie Fradet ⁵Manon Taupin ⁷Denis Cochonneau ⁸Emilie Ollivier ⁸Frank Driessler ⁹Claudia Lange¹⁰

作者信息

1. Nantes University Hospital,Department of Hemostasis,Nantes,France||Nantes Université,CNRS,UMR6286,US2B,2 Rue de la Houssinière,44322 Nantes,France||Institut de Cancérologie de l'Ouest,Heterogeneity and Precision Medicine laboratory,Blvd Jacques Monod,44805 Saint-Herblain,France
2. Bayer AG,Translational Sciences/Omics Research,Wuppertal,Germany
3. Nantes Université,CNRS,UMR6286,US2B,2 Rue de la Houssinière,44322 Nantes,France||Institut de Cancérologie de l'Ouest,Heterogeneity and Precision Medicine laboratory,Blvd Jacques Monod,44805 Saint-Herblain,France||Institut de Cancérologie de l'Ouest,Pathology Research Platform,Saint-Herblain,France
4. Nantes Université,CNRS,UMR6286,US2B,2 Rue de la Houssinière,44322 Nantes,France||Institut de Cancérologie de l'Ouest,Heterogeneity and Precision Medicine laboratory,Blvd Jacques Monod,44805 Saint-Herblain,France||University of Sheffield,School of Medicine and Population Health,Sheffield,UK
5. Nantes Université,CNRS,UMR6286,US2B,2 Rue de la Houssinière,44322 Nantes,France||Institut de Cancérologie de l'Ouest,Heterogeneity and Precision Medicine laboratory,Blvd Jacques Monod,44805 Saint-Herblain,France
6. INSERM,Université Paris-Saclay,U1176,Paris,France
7. Institut de Cancérologie de l'Ouest,Pathology Research Platform,Saint-Herblain,France
8. Institut de Cancérologie de l'Ouest,Heterogeneity and Precision Medicine laboratory,Blvd Jacques Monod,44805 Saint-Herblain,France
9. Bayer Consumer Care AG,TA Medical Affairs Hematology,Basel,Switzerland
10. Bayer AG,Precision Medicine Markers,Berlin,Germany
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摘要

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Antoine Babuty,Oleksandr Boychenko,Marie-Françoise Heymann,Dominique Heymann,Javier Muñoz-Garcia,Olivier D.Christophe,Laurie Fradet,Manon Taupin,Denis Cochonneau,Emilie Ollivier,Frank Driessler,Claudia Lange..Factor Ⅷ restores bone parameters and modulates muscle proteo-metabolome in Factor Ⅷ knockout male mice[J].骨研究（英文版）,2026,14(2):507-523,17.

基金项目

Medical writing for this manuscript was assisted by MPIYP(MC Béné),Paris,France.The authors would like to thank Alicia Grunow and Christian Schultewolter,Bayer AG,for LC-MS proteomics and metabolomics analysis.Authors would also want to acknowledge the IBISA MicroPICell facility(Biogenouest),a member of the national infrastructure France-Bioimaging supported by the French National Research Agency(ANR-10-INBS-04). （MC Béné）

骨研究（英文版）

ISSN：2095-4700

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