广西医学2026，Vol.48Issue(4)：481-486,6.DOI:10.11675/j.issn.0253-4304.2026.04.07
卡瑞利珠单抗联合呋喹替尼治疗晚期微卫星稳定型结直肠癌的疗效分析
Efficacy analysis of camrelizumab combined with fruquintinib for the treatment of advanced microsatellite stable colorectal cancer
摘要
Abstract
Objective To analyze the efficacy of camrelizumab combined with fruquintinib for the treatment of advanced microsatellite stable(MSS)colorectal cancer.Methods A total of 86 patients with advanced MSS colorectal cancer were randomly divided into observation group(n=43,treated with camrelizumab combined with fruquintinib)or control group(n=43,treated with fruquintinib).The clinical efficacy,pre-and post-treatment tumor marker(serum carbohydrate antigen[CA]125,CA199,carcinoembryonic antigen[CEA]),and serological parameters with respect to transforming growth factor β(TGF-β),vascular endothelial growth factor(VEGF),as well as adverse reactions,and progression free survival(PFS)were compared between the two groups.Results The disease control rate and objective response rate in the observation group were higher than those in the control group(P<0.05).After 2 cycles of treatment,levels of serum CA125,CA199,CEA,TGF-β,and VEGF in both groups decreased as compared with before treatment,and the above indicators in the observation group were lower than those in the control group(P<0.05).There was no statistically significant difference in the overall incidence rates of adverse reactions between the two groups(P>0.05).After 1 year of follow-up,the median PFS in the observation group was longer than that in the control group(P<0.05).Conclusion Camrelizumab combined with fruquintinib has a definite efficacy for the treatment of advanced MSS colorectal cancer,reducing levels of serum TGF-β,VEGF,and tumor markers in patients,prolonging PFS of patients,with a favorable safety.关键词
晚期结直肠癌/卡瑞利珠单抗/呋喹替尼/微卫星稳定型/临床疗效/肿瘤标志物Key words
Advanced colorectal cancer/Camrelizumab/Fruquintinib/Microsatellite stable/Clinical efficacy/Tumor markers分类
医药卫生引用本文复制引用
张莉莉,季雯绯,谢勋鹏,张学良..卡瑞利珠单抗联合呋喹替尼治疗晚期微卫星稳定型结直肠癌的疗效分析[J].广西医学,2026,48(4):481-486,6.基金项目
江苏省科技计划项目(BK20230151) （BK20230151）
