广西医学2026，Vol.48Issue(4)：493-498,6.DOI:10.11675/j.issn.0253-4304.2026.04.09
左心室整体纵向应变联合血清肌钙蛋白Ⅰ、N末端B型利钠肽在脓毒症合并心肌病诊断及预后中的预测价值
Predictive value of left ventricular global longitudinal strain combined with serum cardiac troponin Ⅰ and N-terminal pro-B-type natriuretic peptide in the diagnosis and prognosis of sepsis and concomitant cardiomyopathy
摘要
Abstract
Objective To explore the predictive value of left ventricular global longitudinal strain(GLS)combined with serum cardiac troponinⅠ(cTnⅠ)and N-terminal pro-B-type natriuretic peptide(NT-proBNP)in the diagnosis and prognosis of sepsis and concomitant cardiomyopathy.Methods A total of 80 patients with sepsis and concomitant cardiomyopathy were selected as the study group,and 80 patients with sepsis without cardiomyopathy were selected as the control group.After admission,the left ventricular GLS was measured by two-dimensional speckle tracking echocardiography in both groups,and patients'venous blood were collected for detecting the levels of serum cTnⅠ and NT-proBNP.The levels of serum cTnⅠ and NT-proBNP were compared between patients with absolute value of left ventricular GLS>20%and those with absolute value of left ventricular GLS≤20%in the study group.The correlation between left ventricular GLS and serum cTnⅠ and NT-proBNP levels was analyzed by Pearson correlation method.Both groups were continuously treated and observed for 28 days,and the 28-day mortality rate was calculated.The left ventricular GLS and serum cTnI and NT-proBNP levels were compared between the study group and the control group,and between the deceased and the survived patients in the study group.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of left ventricular GLS and serum cTnⅠ and NT-proBNP levels in the diagnosis and prognosis of sepsis and concomitant cardiomyopathy.Results The absolute value of left ventricular GLS in the study group was lower than that in the control group,and the levels of serum cTnⅠ and NT-proBNP and the 28-day mortality rate were higher than those in the control group(P<0.05).The levels of serum cTnⅠ and NT-proBNP in patients with absolute value of left ventricular GLS>20%in the study group were lower than those in patients with absolute value of left ventricular GLS≤20%in the study group(P<0.05).The Pearson correlation analysis results revealed that the left ventricular GLS absolute value negatively correlated with the levels of serum cTnⅠ and NT-proBNP in the study group(P<0.05).The absolute value of left ventricular GLS in deceased patients in the study group was lower than that in survived patients in the study group,and the levels of serum cTnⅠ and NT-proBNP were higher than those in survived patients in the study group(P<0.05).The results of ROC curve analysis indicated that the area under the curve of left ventricular GLS absolute value,serum cTnⅠ and NT-proBNP levels for alone predicting the occurrence and prognosis of sepsis and concomitant cardiomyopathy was greater than 0.5,and the area under the curve of the combination detection of the three was the largest.Conclusion The absolute value of left ventricular GLS is decreased while the levels of serum cTnⅠ and NT-proBNP are elevated in patients with sepsis and concomitant cardiomyopathy.The combined detection of the three can effectively diagnose sepsis and concomitant cardiomyopathy and predict its adverse prognosis risk.关键词
脓毒症/心肌病/左心室整体纵向应变/肌钙蛋白Ⅰ/N末端B型利钠肽/预测价值Key words
Sepsis/Cardiomyopathy/Left ventricular global longitudinal strain/Cardiac troponin Ⅰ/N-terminal pro-B-type natriuretic peptide/Predictive value分类
医药卫生引用本文复制引用
方笑媚,莫绮君,陈柳萍..左心室整体纵向应变联合血清肌钙蛋白Ⅰ、N末端B型利钠肽在脓毒症合并心肌病诊断及预后中的预测价值[J].广西医学,2026,48(4):493-498,6.基金项目
东莞市社会发展科技项目(20231800936882) （20231800936882）
