广州中医药大学学报2026，Vol.43Issue(5)：1123-1133,11.DOI:10.13359/j.cnki.gzxbtcm.2026.05.001
血脂异常痰浊阻遏证和脾肾阳虚证患者血清27-HC、CPT1浓度水平特点及其典型相关性分析
Characteristics and Canonical Correlation Analysis of Serum 27-HC and CPT1 Levels in Patients with Dyslipidemia of Phlegm-Dampness Retention Syndrome and Spleen-Kidney Yang Deficiency Syndrome
摘要
Abstract
Objective To investigate the characteristics of serum 27-hydroxycholesterol(27-HC)and carnitine palmitoyltransferase 1(CPT1)levels and their canonical correlations in patients with dyslipidemia of phlegm-dampness retention syndrome and spleen-kidney yang deficiency syndrome.Methods A cross-sectional field survey epidemiological study was conducted.A total of 58 patients with dyslipidemia who visited Dongzhimen Hospital,Beijing University of Chinese Medicine from May 2021 to February 2025 were enrolled,including 29 patients with phlegm-dampness retention syndrome and 29 patients with spleen-kidney yang deficiency syndrome.Additionally,22 healthy controls(normal group)were included,totaling 80 participants.Serum levels of 27-HC and CPT1 were measured using enzyme-linked immunosorbent assay(ELISA).The severity of syndromes was assessed using TCM syndrome scores obtained from a TCM syndrome rating scale.The characteristics of serum 27-HC and CPT1 levels in patients with dyslipidemia of phlegm-dampness retention syndrome and spleen-kidney yang deficiency syndrome were analyzed,and the canonical correlations between the levels of these oxidative stress-related factors and TCM syndromes were investigated.Results(1)There were no statistically significant differences in general characteristics(age,respiratory rate,heart rate,blood pressure)and disease-related indicators[total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),fasting blood glucose(FBG)]between patients with dyslipidemia of phlegm-dampness retention syndrome and spleen-kidney yang deficiency syndrome(P＞0.05).(2)Serum 27-HC levels in the normal group were significantly lower than those in patients with dyslipidemia of phlegm-dampness retention syndrome(P＜0.05),while serum CPT1 levels were significantly higher(P＜0.05).Serum 27-HC levels in patients with phlegm-dampness retention syndrome were significantly higher than those in patients with spleen-kidney yang deficiency syndrome(P＜0.05),while serum CPT1 levels were significantly lower(P＜0.05).(3)Serum CPT1 levels were negatively correlated with TCM syndrome scores in patients with dyslipidemia of both phlegm-dampness retention syndrome and spleen-kidney yang deficiency syndrome(P＜0.05).(4)Canonical correlation analysis indicated that serum CPT1 level had the most significant impact on TCM syndrome scores,and TCM syndrome scores in patients with phlegm-dampness retention syndrome had the most significant impact on the levels of oxidative stress indicators.Conclusion Serum levels of 27-HC and CPT1 differ between patients with dyslipidemia of phlegm-dampness retention syndrome and spleen-kidney yang deficiency syndrome.Serum CPT1 levels may reflect the severity of TCM syndromes in patients with dyslipidemia to some extent.Vascular endothelial injury resulting from enhanced oxidative stress characterizes the syndrome of phlegm-dampness retention syndrome in dyslipidemia,with macrophages playing a key role.The underlying mechanism may involve vascular endothelial injury caused by enhanced oxidative stress due to metabolic elasticity dysregulation.关键词
血脂异常/痰浊阻遏证/脾肾阳虚证/27-羟基胆固醇/肉碱棕榈酰转移酶1/代谢弹性失调/氧化应激/血管内皮损伤/典型相关性分类
医药卫生引用本文复制引用
田筱雅,薛晓琳,叶超,谢琼,季昭宇,陈心怡,陈睿知,芮晓辰,陈婧..血脂异常痰浊阻遏证和脾肾阳虚证患者血清27-HC、CPT1浓度水平特点及其典型相关性分析[J].广州中医药大学学报,2026,43(5):1123-1133,11.基金项目
国家自然科学基金青年科学基金项目(编号:82004237) （编号:82004237）
北京市自然科学基金面上项目(编号:7242233) （编号:7242233）
北京中医药大学中央高校基本科研业务费(揭榜挂帅)项目(编号:2023-JYB-JBQN-044) （揭榜挂帅）
中央高水平中医医院临床科研业务费项目(编号:DZMG-ZLZX-25021) （编号:DZMG-ZLZX-25021）
北京高层次创新创业人才支持计划(春蕾)项目(京卫人才[2025]2号) （春蕾）
北京中医药新时代125工程培训项目(京中医药科字[2025]2号) （京中医药科字[2025]2号）
北京中医药大学第三附属医院精诚人才(精诚青苗)项目 （精诚青苗）
