海南医科大学学报2026，Vol.32Issue(8)：624-630,7.DOI:10.13210/j.cnki.jhmu.20250515.002
外周血miR-155水平对脓毒症及肠道功能障碍患者28d死亡风险的预测价值
Predictive value of peripheral blood miR-155 levels on the risk of death at 28 d in patients with sepsis and intestinal dysfunction
摘要
Abstract
Objective:To analyze the predictive value of peripheral blood microRNA-155(miR-155)concentration on the risk of death within 28 days in patients with sepsis and intestinal dysfunction.Methods:This study focused on 129 cases of sepsis ad-mitted to the Critical Medicine Center of the First Affiliated Hospital of Xinjiang Medical University.Logistic regression model was used to explore the correlation between the expression of miR-155 in peripheral blood and the occurrence of intestinal dysfunc-tion.According to the life and death status of patients within 28 days,the samples were divided into the survival group(n=93)and the death group(n=36).Cox proportional risk model was used to identify the risk factors affecting the prognosis of sepsis pa-tients,and the receiver operating characteristic curve(ROC)of the subjects was constructed based on this model to evaluate the ef-ficacy of peripheral blood miR-155 expression level in predicting the prognosis of sepsis patients.In addition,Kaplan-Meier surviv-al analysis was used to draw survival curves according to different miR-155 expression levels for in-depth survival analysis.Re-sults:The increased expression of miR-155 in peripheral blood of patients with sepsis was a risk factor for induced intestinal dys-function(OR=3.156,95%CI=1.875‒5.311,P<0.001).Compared to the survival group,the expression level of miR-155 in peripheral blood of patients in the death group was significantly increased(P<0.001).Cox proportional hazard regression analysis further confirmed that miR-155 was a key factor independently affecting the prognosis of sepsis patients.According to the ROC curve analysis,the AUC of miR-155 expression level was 0.962 when predicting the 28-day death risk of sepsis patients,indicat-ing a high prediction accuracy.When the cut-off value of miR-155 was set to 3.95,the predicted sensitivity reached 93.9%and the specificity was 90.2%.Kaplan-Meier survival curve analysis further revealed that patients with miR-155 expression levels above 3.95 had a significantly worse prognosis(P<0.001).Conclusions:As a simple,efficient,and safe biomarker,miR-155 in periph-eral blood has clinical potential in the prediction and early prognosis assessment of sepsis and intestinal injuries caused by sepsis.关键词
脓毒症/肠道功能障碍/miR-155/28d死亡风险Key words
Sepsis/Intestinal dysfunction/miR-155/28-day mortality risk分类
医药卫生引用本文复制引用
李志华,银乐乐,杨春波,于湘友,高晓明,王毅..外周血miR-155水平对脓毒症及肠道功能障碍患者28d死亡风险的预测价值[J].海南医科大学学报,2026,32(8):624-630,7.基金项目
This study was supported by the National Natural Science Foundationof China(82160360) （82160360）
Natural Science Foundation Project of Xinjiang Uygur Autonomous Region(2022D01C477) （2022D01C477）
14th Five Year Plan for National Key Research and Development Program of China(2021YFC25000801) 国家自然科学基金(82160360) （2021YFC25000801）
新疆维吾尔自治区自然科学基金(2022D01C477) （2022D01C477）
"十四五"国家重点研发计划(2021YFC25000801) （2021YFC25000801）
