海南医科大学学报2026，Vol.32Issue(8)：631-640,10.DOI:10.13210/j.cnki.jhmu.20250716.001
多酚类天然化合物防治结直肠癌的研究进展
Research progress on polyphenolic natural compounds in the prevention and treatment of colorectal cancer
摘要
Abstract
Colorectal cancer ranks as the second most common cause of cancer mortality globally.Given the disease's intricate pathogenic mechanisms and the significant adverse effects frequently associated with conventional radiation and chemotherapy,identifying novel natural compounds with minimal toxicity for alternative or complementary therapies has become imperative.Emerging research indicates that natural polyphenols exhibit substantial potential in both the treatment and prevention of colorectal cancer.These compounds may exert their anti-cancer properties through diverse pathways,including inflammation suppression,proliferation inhibition,apoptosis induction,drug resistance modulation,and gut microbiome regulation.This paper synthesizes current advancements in polyphenol-based colorectal cancer research,elucidates their multifaceted anti-tumor mechanisms,and ex-plores strategies to improve their therapeutic bioavailability and targeting specificity,thereby offering innovative perspectives for clinical management.关键词
多酚/结直肠癌/生物利用度/载体Key words
Polyphenols/Colorectal cancer(CRC)/Bioavailability/Delivery systems分类
医药卫生引用本文复制引用
黄熠,郑新烨,赵紫微,黄怡婷,吴美珠,陈友琴,沈阿灵..多酚类天然化合物防治结直肠癌的研究进展[J].海南医科大学学报,2026,32(8):631-640,10.基金项目
This study was supported by the Youth Talent Support Program from Fujian Research and Training Grants for Young and Middle-Aged Leaders in Healthcare （）
the Scientific Research Foundation for the Top Youth Talents of Fujian University of Traditional Chinese Medicine(XQB202202) 第三批福建省卫生健康中青年领军人才研修培养项目 （XQB202202）
2022年度校青年科研拔尖人才项目(XQB202202) （XQB202202）
