广州中医药大学学报2026，Vol.43Issue(5)：1201-1207,7.DOI:10.13359/j.cnki.gzxbtcm.2026.05.010
加味达原饮治疗气虚湿阻型产妇剖宫产术后肠麻痹的临床观察
Clinical Observation of Modified Dayuan Decoction in the Treatment of Post-Cesarean Section Paralytic Ileus of Qi Deficiency and Dampness Obstruction Type in Puerperae
摘要
Abstract
Objective To observe the clinical efficacy of Modified Dayuan Decoction in the treatment of post-cesarean section paralytic ileus of qi deficiency and dampness obstruction type,and to assess its effects on gastrointestinal function and inflammatory factor levels.Methods A total of 80 patients diagnosed with post-cesarean section paralytic ileus of qi deficiency and dampness obstruction type after undergoing lower uterine segment transverse incision cesarean section in the Department of Obstetrics and Gynecology,Dongguan Hospital of Guangzhou University of Chinese Medicine(Dongguan Traditional Chinese Medicine Hospital)from May 2024 to May 2025 were randomly divided into a control group and an trial group using a complete random method,with 40 cases in each group.Both groups received routine postoperative care and external traditional Chinese meidcine(TCM)therapies.On this basis,the control group was not given any prokinetic drug intervention,while the trial group was treated orally with Modified Dayuan Decoction for a course of 3 days.The recovery time of bowel sounds,time to first flatus,and time to first defecation were compared between the two groups after treatment.Changes in TCM syndrome scores,Numerical Rating Scale(NRS)scores for abdominal pain,and serum levels of interleukin-6(IL-6),interleukin-10(IL-10),tumor necrosis factor-alpha(TNF-α),and interferon-gamma(IFN-γ)were observed before and after treatment(immediately after surgery and 72 hours after surgery)in both groups,and the clinical efficacy was evaluated.Results(1)Regarding efficacy,after 3 days of treatment,the total effective rate was 100.0%(40/40)in the trial group and 85.0%(34/40)in the control group,and intergroup comparison(by chi-square test)showed that the efficacy of the trial group was significantly superior to that of the control group(P＜0.05).(2)Regarding gastrointestinal function recovery,the recovery time of bowel sounds,time to first flatus,and time to first defecation after cesarean section were significantly shorter in the trial group than those in the control group(P＜0.05 or P＜0.01).(3)Regarding TCM syndrome scores,there were no statistically significant differences between the two groups immediately after surgery(0 hour)and 6 hours after surgery(P＞0.05).At 24,48 hours,and 72 hours after surgery,TCM syndrome scores in both groups were significantly decreased compared to immediately after surgery(P＜0.05),and the decreases were significantly greater in the trial group than in the control group(P＜0.01).(4)Regarding abdominal pain assessment,no statistically significant difference was found in NRS abdominal pain scores between the two groups immediately after surgery(P＞0.05).At 12 hours and 24 hours after surgery,NRS scores in both groups were significantly decreased compared to immediately after surgery(P＜0.05),and the decreases were significantly greater in the trial group than in the control group(P＜0.01).(5)Regarding inflammatory factors,in the control group,serum levels of IL-10,TNF-α,and IFN-γ were significantly increased after 3 days of treatment compared to before treatment(P＜0.01),while serum IL-6 level showed an increasing trend but without statistical significance(P＞0.05).In the trial group,serum levels of IL-6,TNF-α,and IFN-γ were significantly decreased after 3 days of treatment compared to before treatment(P＜0.05),while serum IL-10 level showed a decreasing trend but without statistical significance(P＞0.05).After treatment,serum levels of IL-6,IL-10,TNF-α,and IFN-γ in the trial group were significantly lower than those in the control group(P＜0.05).Conclusion Modified Dayuan Decoction demonstrates significant efficacy in treating post-cesarean section paralytic ileus of qi deficiency and dampness obstruction type,and is effective on improving gastrointestinal function,alleviating abdominal pain symptoms,and regulating serum inflammatory factor levels.关键词
加味达原饮/剖宫产术后/肠麻痹/气虚湿阻型/胃肠功能/炎症因子Key words
Modified Dayuan Decoction/post-cesarean section/paralytic ileus/qi deficiency and dampness obstruction type/gastrointestinal function/inflammatory factors分类
医药卫生引用本文复制引用
伍颖华,王乃平,董明国,程晓榆,陈淑莹..加味达原饮治疗气虚湿阻型产妇剖宫产术后肠麻痹的临床观察[J].广州中医药大学学报,2026,43(5):1201-1207,7.基金项目
广东省基础与应用基础研究基金省企联合基金面上项目(编号:2021A15150094) （编号:2021A15150094）
东莞市社会发展科技项目高水平医院建设专项(编号:20231800927372) （编号:20231800927372）
