广州中医药大学学报2026，Vol.43Issue(5)：1409-1418,10.DOI:10.13359/j.cnki.gzxbtcm.2026.05.038
基于隐结构模型结合关联规则分析探讨中药治疗肺心病的用药规律
Exploration of Medication Rules of Chinese Medicine in Treating Pulmonary Heart Disease Based on Latent Structure Model and Association Rule Analysis
摘要
Abstract
Objective To systematically analyze high-frequency Chinese medicinals used in the treatment of pulmonary heart disease by constructing a latent structure model and applying association rule algorithms,thereby revealing medication rules and providing evidence-based support for the optimization of clinical protocols,enhancement of therapeutic efficacy,and formulation of relevant guidelines.Methods Clinical research on the treatment of pulmonary heart disease with Chinese medicine was retrieved from the China National Knowledge Infrastructure,VIP Database,Wanfang Data Knowledge Service Platform,and China Biomedical Database,covering the period from the inception of each database to March 2025.NoteExpress software was employed for literature screening,and then eligible data were imported into Microsoft Excel 2019 for statistical analysis of medication frequency,efficacy classification,and distribution of nature,flavor,and meridian tropism of the herbs.Lantern 5.0 and R-Studio software were used to construct a latent structure model and perform association rule analysis on high-frequency Chinese medicinals,aiming to explore medication rules and infer traditional Chinese medicine syndrome types.Results A total of 508 medical records involving 300 Chinese medicinals were ultimately included.Forty-one high-frequency Chinese medicinals with a frequency≥40 were identified,among which the most frequently-used herbs were Poria,Pinelliae Rhizoma,Atractylodis Macrocephalae Rhizoma,Astragali Radix,Descurainiae seu Lepidii Semen,Glycyrrhizae Radix et Rhizoma,Cinnamomi Ramulus,Armeniacae Semen Amarum,Aconiti Lateralis Radix Praeparatam,Schisandrae Chinensis Fructus,Perillae Fructus,etc.The high-frequency medicinals were classified into 12 categories according to the efficacy,and the commonly-used types were herbs for promoting diuresis and alleviating edema,herbs for inducing diuresis and draining dampness,herbs for drying dampness and resolving phlegm,and herbs for activating blood and removing stasis.In terms of the properties of the herbs,warm nature was predominated,and the flavors were primarily sweet,pungent,and bitter.The high-frequency medicinals usually have the meridian tropism of the lung,spleen,and heart meridians.Latent structure analysis yielded 26 latent variables,6 comprehensive clustering models,and 12 core formulas.Based on formula-syndrome inference,six common syndrome types of pulmonary heart disease were identified,and they were heart-lung qi deficiency syndrome,cold congealing heart-lung syndrome,phlegm-turbidity obstruction syndrome,blood stasis blocking collaterals syndrome,qi stagnation in chest syndrome,and yang deficiency with fluid retention syndrome,which were correspondingly treated with Shengmai San and Baoyuan Decoction,Xiaoqinglong Decoction and Zhishi Xiebai Guizhi Decoction,Gualou Xiebai Banxia Decoction and Ditan Decoction,Xuefu Zhuyu Decoction and Danshen Decoction,Chaihu Shugan San and Wendan Decoction,Zhenwu Decoction and Tingli Dazao Xiefei Decoction.Association rule analysis identified 28 strong association rules,with the medicinal combination of Atractylodis Macrocephalae Rhizoma and Poria having the highest support,and observed for the herbal group of Cinnamomi Ramulus,Alismatis Rhizoma and Poria having the highest confidence.Conclusion Pulmonary heart disease is characterized by deficiency in the root and excess in the branch,with root deficiency primarily manifesting as qi deficiency and yang deficiency,and branch excess predominantly associated with the pathological factors of phlegm turbidity,retained fluid,and blood stasis.Its core pathogenesis of phlegm-stasis obstructing the lung and heart-kidney yang deficiency is closely related to the dysfunction of the lung,heart,and spleen.The common syndrome types of pulmonary heart disease are heart-lung qi deficiency syndrome,cold congealing heart-lung syndrome,phlegm-turbidity obstruction syndrome,blood stasis blocking collaterals syndrome,qi stagnation in the chest syndrome,and yang deficiency with fluid retention syndrome.Treatment primarily focuses on warming yang and promoting diuresis,strengthening the spleen and resolving phlegm,supplemented by the methods of ventilating the lung and resolving phlegm,and activating blood and resolving stasis according to syndrome differentiation.The identified high-frequency medicinals and core formulas provide evidence-based references for the clinical management of pulmonary heart disease with Chinese medicine and for the formulation of relevant guidelines.关键词
肺心病/隐结构模型/关联规则分析/心肺气虚证/寒凝心肺证/痰浊闭阻证/生脉散/保元汤/方药规律Key words
pulmonary heart disease/latent structure model/association rule analysis/heart-lung qi deficiency syndrome/cold congealing heart-lung syndrome/phlegm-turbidity obstruction syndrome/Shengmai San/Baoyuan Decoction/medication rules分类
医药卫生引用本文复制引用
柴苑如,铁梦意,吴广,王大伟..基于隐结构模型结合关联规则分析探讨中药治疗肺心病的用药规律[J].广州中医药大学学报,2026,43(5):1409-1418,10.基金项目
国家自然科学基金面上项目(编号:82374239) （编号:82374239）
中医药广东省实验室项目(编号:HOL2024PZ028) （编号:HOL2024PZ028）
中医证候全国重点实验室项目(编号:2020B1111100004) （编号:2020B1111100004）
