广州化学2026，Vol.51Issue(2)：33-39,7.DOI:10.16560/j.cnki.gzhx.20252665
PLGA封装GE11肽偶联锌酞菁纳米光敏剂的制备及体外生物评价
PLGA-Encapsulated GE11 Peptide-Conjugated Zinc Phthalocyanine Nanophotosensitizer:Preparation and in Vitro Biological Evaluation
蒙素仟 1王云龙 1桑柳波 2唐毅 2靳焘3
作者信息
- 1. 中国科学院广州化学研究所,广东 广州 510650||中科检测技术服务(广州)股份有限公司,广东 广州 510650||中国科学院大学,北京 100049
- 2. 中科广化(重庆)新材料研究院有限公司,重庆 401338
- 3. 中国科学院广州化学研究所,广东 广州 510650||中科检测技术服务(广州)股份有限公司,广东 广州 510650||中国科学院大学,北京 100049||中科广化(重庆)新材料研究院有限公司,重庆 401338||中国科学院新型特种精细化学品工程实验室,广东 广州 510650||国科广化韶关新材料研究院,广东韶关 512122||国科广化精细化工孵化器(南雄)有限公司,广东 南雄 512400
- 折叠
摘要
Abstract
Phthalocyanine photosensitizers with high molar extinction coefficients and a biological therapeutic window,exhibit great PDT potential.However,their planar conjugated structure causes hydrophobicity,leading to aggregation in aqueous systems and low tissue-targeting selectivity,limited tumor accumulation and potential healthy tissue damage.To overcome these limitations,this study conjugated 1-sulfonatophenoxy zinc phthalocyanine(ZnPcS)with the GE11 peptide and encapsulated poly(lactic-co-glycolic acid)(PLGA)to form the nanophotosensitizer(PLGA@GE11-ZnPcS).This study used NMR,FT-IR,UV-Vis,etc.to validate the molecular structure,optical properties,nanoparticle size and distribution.Electron paramagnetic resonance(EPR)and 1,3-diphenylisobenzofuran(DPBF)assays evaluated the singlet oxygen generation.PLGA@GE11-ZnPcS showed good water solubility,efficient light activation and outstanding singlet oxygen generation ability.In vitro cell tests indicated good cell compatibility in the dark and remarkable photodynamic anti-tumor activity upon light irradiation.Hemolysis tests verified that the nanophotosensitizer caused no red blood cell hemolysis,indicating in-vivo safety.In conclusion,PLGA@GE11-ZnPcS showed high biosafety and anti-tumor activity,making it a promising candidate for photodynamic tumor therapy and potential drug-resistant bacteria sterilization.However,the high synthesis cost and poor physiological stability of the GE11 peptide currently limit its widespread use in tumor therapy.关键词
光动力疗法/酞菁光敏剂/GE11肽/PLGA共聚物/生物相容性/抗肿瘤活性Key words
photodynamic therapy/phthalocyanine photosensitizer/GE11 peptide/poly(lactic-co-glycolic acid)copolymer/biocompatibility/antitumor activity分类
化学化工引用本文复制引用
蒙素仟,王云龙,桑柳波,唐毅,靳焘..PLGA封装GE11肽偶联锌酞菁纳米光敏剂的制备及体外生物评价[J].广州化学,2026,51(2):33-39,7.
