广州化学2026，Vol.51Issue(2)：47-53,7.DOI:10.16560/j.cnki.gzhx.20252669
拆解-重构策略制备蚕茧基Janus复合止血材料及性能
Preparation and Properties of Cocoon-Based Janus Hemostatic Materials via Disassembly-Reconstruction
摘要
Abstract
A hierarchical reassembly strategy was employed to fabricate a silk cocoon-based composite hemostatic material(SC-C)through processes including delamination,controlled dissolution,hot pressing,and hydrophobic modification.Fundamental characterizations were conducted using SEM,FTIR,and XRD.Water contact angle(WCA)and water vapor transmission rate(WVTR)were also measured.Results showed that the inner surface of SC-C could completely absorb water within 1.5 seconds,while the outer surface remained hydrophobic(WCA=119.3°)The WVTR decreased to 2351 g/(m2 d),falling within the optimal range for wound dressings.The Janus structure allowed the hydrophilic inner surface to adhere to tissue while the hydrophobic outer surface prevented excessive blood permeation.SC-C demonstrated excellent blood compatibility(hemolysis ratio＜2％),and both blood loss and hemostasis time were significantly reduced compared to SC alone and commercial hydrocolloid dressings,indicating outstanding hemostatic performance.关键词
蚕茧/梯度结构/止血材料/Janus结构Key words
silk cocoon/gradient structure/hemostatic material/Janus structure分类
轻工纺织引用本文复制引用
陈茂林,刘向东,付飞亚..拆解-重构策略制备蚕茧基Janus复合止血材料及性能[J].广州化学,2026,51(2):47-53,7.基金项目
校企产学研合作项目[低共熔溶剂法回收丝蛋白工艺开发(24210865-J)] （24210865-J）
