On the auspicious occasion of her 95th birthday,this paper is dedicated to Professor Youyou Tu,the esteemed recipient of the 2015 Nobel Prize in Physiology or Medicine,in recognition of her groundbreaking discovery of Artemisinin,which has saved millions of lives worldwide.We thank Syngenta for the fellowship awarded to Yan-Wei Wu and Qun Zhang.We are grateful to Professor Zhi-Yuan Gong,National University of Singapore,for providing the TO(krasG12V)zebrafish.We also thank Addgene for providing pcDNA3.1-VEGFR2-mCherry.This work was supported by the Special Funds of Shandong Province for Qingdao Marine Science and Technology Center(No.2022QNLM030003-2 and No.2022QNLM030003-3),the Program of National Natural Science Foundation of China(Nos.42376116,41322037,U1706210),Shandong Province Special Fund"Frontier Technology and Free Exploration"from Laoshan Laboratory(No.8-01),the State Key Laboratory for Chemistry and Molecular Engi-neering of Medicinal Resources,Guangxi Normal University(No.CMEMR2023-B16),the Taishan Scholars Program of China,and the Innovation Center for Academicians of Hainan Province. （krasG12V）