南京医科大学学报（自然科学版）2026，Vol.46Issue(5)：725-738,14.DOI:10.7655/NYDXBNSN251206
氨基酸代谢紊乱在冠心病发生发展中的作用机制及临床意义
The role of amino acid metabolism disorders in the pathogenesis and clinical significance of coronary heart disease
摘要
Abstract
Given the close association between amino acid metabolism disorders and the occurrence and progression of coronary heart disease(CHD),this article aims to systematically summarize the correlations,mechanisms of action,and clinical application prospects of relevant amino acid metabolic abnormalities with CHD.A systematic review approach was adopted to analyze the role of metabolic abnormalities of homocysteine,branched-chain amino acids,aromatic amino acids,and other amino acids in CHD-related pathological processes.Meanwhile,the potential impacts of amino acid metabolites and gut microbiota on CHD were explored.Multiple amino acid metabolic abnormalities were confirmed to be associated with CHD risk,which influence disease progression by participating in pathological processes such as atherosclerosis,thrombosis,and endothelial dysfunction.Amino acid metabolism indicators have shown promising clinical application potential in CHD risk prediction,auxiliary diagnosis,and therapeutic intervention.Despite existing contradictions and limitations in current research,amino acid metabolism disorders,as a new target for CHD prevention and treatment,hold clinical value and research potential,providing a new direction for cardiovascular disease research.关键词
氨基酸代谢紊乱/冠心病/同型半胱氨酸/支链氨基酸/芳香族氨基酸/动脉粥样硬化/风险预测Key words
amino acid metabolism disorder/coronary heart disease/homocysteine/branched-chain amino acid/aromatic amino acid/atherosclerosis/risk prediction分类
医药卫生引用本文复制引用
崔入元,任琼迪,朱明军..氨基酸代谢紊乱在冠心病发生发展中的作用机制及临床意义[J].南京医科大学学报（自然科学版）,2026,46(5):725-738,14.基金项目
国家科技重大专项(2024ZD0522000) （2024ZD0522000）
河南省重点研发专项(23111310200) （23111310200）
国家中医药高层次人才-岐黄学者支持项目(CZ0277) （CZ0277）
