辽宁中医药大学学报2026，Vol.28Issue(5)：40-48,9.DOI:10.13194/j.issn.1673-842X.2026.05.007
抑郁症慢性不可预知温和刺激动物模型分析及评价
Analysis and Evaluation of Chronic Unpredictable Mild Stimulus Animal Model for Depression
摘要
Abstract
Objective To analyze the modeling characteristics of chronic unpredictable mild stimulation(CUMS)animal models of depression in China,and explore depression models that are more suitable for the disease.Methods Using"CUMS"and"animal models"as keywords,search for relevant literature on animal experiments from the China National Knowledge Infrastructure database until May 2024,and summarize animal species,modeling methods,detection indicators,etc.After one week of adaptive feeding,male SD rats were randomly divided into a control group and a CUMS model group.The two groups were treated according to different modeling methods,and after 21 days of modeling,relevant behavioral tests and hippocampal HE staining were performed.Results A total of 332 standard literature were included,with male animals being the majority,including SD rats(226 times,68.07%),Wistar rats(40 times,12.05%),and C57BL/6J mice(30 times,9.04%);The main molding cycles are 21 days(75 times),42 days(67 times),and 28 days(65 times).The success of modeling is mainly based on animal body mass,behavior,molecular testing,etc.The pathology was mostly hippocampal HE staining.After 21 days of CUMS combined with solitary confinement,the model group showed decrease in body weight,food intake,sucrose preference,and total distance of open field compared to the control group.The number and duration of forced swimming and floating increased(P<0.05).Hippocampal tissues were subjected to hematoxylin and eosin(HE)staining for pathological morphological evaluation.Conclusion The CUMS combined with solitary care model showed a decrease in body weight,food intake,sucrose preference,and total open field distance,with an increase in resting time,and the modeling was basically successful.关键词
抑郁症/慢性不可预知温和刺激/动物模型/数据挖掘/模型评价Key words
major depression disorder/chronic unpredictable mild stimulation/animal model/data mining/model evaluation分类
医药卫生引用本文复制引用
蒲珊珊,杨丽蓉,陈炜,朱小敏,卓桂锋,张金枝,吴林..抑郁症慢性不可预知温和刺激动物模型分析及评价[J].辽宁中医药大学学报,2026,28(5):40-48,9.基金项目
国家自然科学基金项目(82374387,82160885) （82374387,82160885）
国家中医药管理局高水平重点学科中医内科学项目(ZYYZDXK-2023166) （ZYYZDXK-2023166）
广西中医药重点学科建设项目(GZXK-Z-20-13) （GZXK-Z-20-13）
广西中医药大学第一附属医院学术团队建设项目(院字[2018]146号) （院字[2018]146号）
