辽宁中医药大学学报2026，Vol.28Issue(5)：49-53,5.DOI:10.13194/j.issn.1673-842X.2026.05.008
葶苈子有效成分及治疗心力衰竭研究
Effective Ingredient of Tinglizi(Semen Lepidii)and the Treatment of Heart Failure in Clinical Research
摘要
Abstract
Tinglizi(Semen Lepidii)is the dried mature seed of Descurainia sophia(southern Tinglizi)or Lepidium apetalum(northern Tinglizi)from the Cruciferae family,and it has the traditional effects of purging the lung to relieve asthma and inducing diuresis to reduce edema.This article systematically reviews the research progress of Tinglizi(Semen Lepidii)in terms of its active ingredients,pharmacological effects,and clinical application in the treatment of heart failure(HF).At present,its main active ingredients have been clarified into four categories.①Flavonoids:about 60 types have been identified,such as quercetin,kaempferol,lepidiumflavonol D,etc.,among which quercetin-3-O-β-D-glucose-7-O-β-D-gentiobioside is unique to southern Tinglizi(Semen Lepidii);②Thioglycosides:such as the newly discovered descurainoside;③Isothiocyanates:such as degradation products like 3-phenylpropionitrile;④Cardiac glycosides:such as strophanthidin,lepidiin,etc.Pharmacological studies have shown that these ingredients exert comprehensive effects through multiple targets and pathways.Flavonoids can target HSP90AA1 and SRC genes,regulate mitochondrial electron transport and MAPK/PI3K signaling pathways,improve myocardial energy metabolism,and protect mitochondrial function by activating the PPARα/PGC-1α/Sirt3 pathway;Cardiac glycosides can significantly enhance myocardial contractility,with effects equivalent to digitalis drugs;Thioglycosides and isothiocyanates can inhibit the activity of the renin-angiotensin-aldosterone system(RAAS),regulate the expression of aquaporins,and play a role in diuresis and detumescence;In addition,it can also improve myocardial fibrosis by inhibiting the TGF-β/Smad signaling pathway,and exhibit anti-inflammatory,immune regulation,blood lipid regulation,and estrogen-like effects.In the clinical application for heart failure,compound preparations containing Tinglizi(Semen Lepidii)[such as the classic prescription Tinglizi Dazao Xiefei Decoction(葶苈大枣泻肺汤)]have shown significant efficacy.Especially in patients with chronic heart failure,they can increase the left ventricular ejection fraction by about 12.3%and the 6-minute walking distance by about 28.5 meters;in the treatment of rheumatic heart disease with heart failure and refractory heart failure,the total effective rate can reach 85%-96.97%when combined with conventional western medicine;in acute heart failure,it can quickly improve the hemodynamic status of patients and reduce mortality.This article systematically sorts out the research status of Tinglizi(Semen Lepidii),providing an important reference for its in-depth development and safe clinical application.关键词
葶苈子/有效成分/心力衰竭/药理作用/研究进展Key words
Tinglizi(Semen Lepidii)/effective ingredient/heart failure/pharmacologic effects/research progress分类
医药卫生引用本文复制引用
吴佳吉,邹珊芸,范春梅,卢健棋,董礼,肖湘,杨尚冰,毛美玲,甘宇云,胡莉惠,涂雅柔..葶苈子有效成分及治疗心力衰竭研究[J].辽宁中医药大学学报,2026,28(5):49-53,5.基金项目
国家自然科学基金地区基金项目(82160887) （82160887）
国家中医临床研究基地业务建设第二批科研专项课题(JDZΧ2015146) （JDZΧ2015146）
国家中医药传承创新中心项目(2023019-10) （2023019-10）
广西自然科学基金项目(2021GXNSFBA196018) （2021GXNSFBA196018）
广西岐黄学者培养项目(2024005-06-02) （2024005-06-02）
广西自然科学基金面上项目(2021GXNSFAA220111) （2021GXNSFAA220111）
广西中医药管理局自筹经费科研课题(GXZYA20230065) （GXZYA20230065）
广西高水平中医药重点学科-中医心病学项目(2024016-02-02) （2024016-02-02）
南宁市科学研究与技术开发计划项目(20233040) （20233040）
