辽宁中医药大学学报2026，Vol.28Issue(5)：72-84,13.DOI:10.13194/j.issn.1673-842X.2026.05.011
栀子豉汤化学成分、药理作用、临床应用研究进展及质量标志物预测分析
Research Progress of Zhizichi Decoction(栀子豉汤)and Prediction Analysis of Quality Markers
摘要
Abstract
Zhizichi Decoction(栀子豉汤),which has been used up to the present,was first recorded in Treatise on Cold Damage and Miscellaneous Diseases by ZHANG Zhongjing of the Han Dynasty.It is composed of two medicinal ingredients:Zhizi(Gardeniae Fructus)and Dandouchi(Sojae Semen Praeparatum).It has the functions of clearing depression and relieving annoyance,as well as promoting the release of internal heat.It was originally used to treat the syndrome of"heat stagnation in the chest and diaphragm",with symptoms such as restlessness,insomnia,and chest oppression.Modern research shows that the chemical components of Zhizichi Decoction include iridoids,flavonoids,monoterpenes,diterpenes,triterpenes,organic acids,and organic acid esters,etc.These components often vary due to different processing methods of Zhizi(Gardeniae Fructus)and the fermentation differences of Dandouchi(Sojae Semen Praeparatum).The pharmacological effects mainly focus on the fields of neuroprotection and mental improvement,including anti-depression and hypnotic effects.At the same time,it has anti-inflammatory,antioxidant,antibacterial,regulation of intestinal flora,regulation of endocrine,liver protection,and heart protection effects.It has excellent performance in the nervous system,cardiovascular system,digestive system,respiratory system,endocrine system,and gynecological and pediatric diseases.To make the preparation of Zhizichi Decoction more scientific and standardized,based on the summary and review of its chemical components,pharmacological effects,and clinical applications,the Q-Marker of Zhizichi Decoction was predicted and analyzed in accordance with the five principles of Q-Marker,from the aspects of quality transfer and traceability,specificity,effectiveness,compatibility in compound prescriptions,and measurability.It was determined that geniposide,geniposide acid,geniposide-1-O-β-D-gentiobioside,crocin Ⅰ,daidzein,and genistein are the Q-Markers of Zhizichi Decoction,which can provide a reference basis for the subsequent preparation of Zhizichi Decoction and its related preparations.关键词
栀子豉汤/化学成分/药理作用/临床应用/质量标志物Key words
Zhizichi Decoction(栀子豉汤)/chemical components/pharmacological effects/clinical applications/quality markers分类
医药卫生引用本文复制引用
张嘉敏,杜萌萌,周涛..栀子豉汤化学成分、药理作用、临床应用研究进展及质量标志物预测分析[J].辽宁中医药大学学报,2026,28(5):72-84,13.基金项目
国家自然科学基金青年科学基金项目(82405297) （82405297）
中国博士后科学基金项目(2022M711083) （2022M711083）
国家中医临床研究基地科研专项(2022JDZX112) （2022JDZX112）
