辽宁中医药大学学报2026，Vol.28Issue(5)：91-96,6.DOI:10.13194/j.issn.1673-842X.2026.05.013
基于"畅络调神"理论探讨肠-脑轴与功能性胃肠病的关系
Exploration of the Relationship Between Gut-brain Axis and Functional Gastrointestinal Disorders Based on the Theory of"Smoothing the Channels and Regulating the Mind"
摘要
Abstract
Functional gastrointestinal disorders(FGIDs)are complex psychosomatic diseases with gut-brain axis dysfunction as the core pathological mechanism.They are characterized by comorbidity of chronic gastrointestinal symptoms and emotional disorders,with a continuously rising prevalence.Western medicine treatment has problems such as side effects and insufficient long-term efficacy.In Traditional Chinese medicine,it is categorized into"abdominal fullness""diarrhea"and other categories.Based on the"Smoothing the channels and regulating the mind"theory,its core pathogenesis is defined as"collateral stagnation and spirit disorder":intestinal collateral stagnation is associated with modern pathological changes such as intestinal flora imbalance and mucosal barrier injury;deficiency of spirit nourishment is related to mechanisms such as neurotransmitter imbalance and excessive activation of the hypothalamic-pituitary-adrenal axis,forming a vicious circle of mutual impairment between body and spirit;mutual impairment of collaterals and spirit is highly consistent with the bidirectional regulatory imbalance of the gut-brain axis."Smoothing the channels and regulating the mind"can improve intestinal microecology and repair the mucosal barrier by unblocking intestinal collaterals,and regulate the neuro-endocrine-immune network by nourishing the spirit,which can effectively alleviate gastrointestinal symptoms and emotional disorders of FGIDs.It provides clear theoretical guidance and a practical path for the clinical prevention and treatment of FGIDs,and has important clinical application value.关键词
功能性胃肠病/畅络调神/肠-脑轴/发病机制/科学内涵Key words
functional gastrointestinal disorders/Smoothing the channels and regulating the mind/gut-brain axis/pathogenesis/the connotation of science分类
医药卫生引用本文复制引用
贾菁,宁博,牛建海,陈大蕾,刘佳宁,赵明君..基于"畅络调神"理论探讨肠-脑轴与功能性胃肠病的关系[J].辽宁中医药大学学报,2026,28(5):91-96,6.基金项目
国家重点研发计划-中医药现代化研究重点专项(2018YFC1704204) （2018YFC1704204）
陕西省重点研发计划项目(2024SF-ZDCYL-03-21) （2024SF-ZDCYL-03-21）
河北省保定市科技计划项目(2241ZF282) （2241ZF282）
陕西省省级院士工作站建设项目-吴以岭院士工作站(陕组通字[2019]49号-30) （陕组通字[2019]49号-30）
陕西省名中医赵明君传承工作室建设项目(2019007) （2019007）
陕西省教育厅重点科研计划项目(22JS005) （22JS005）
陕西省咸阳市重点研发计划项目(L2023-ZDYF-SF-047) （L2023-ZDYF-SF-047）
