同济大学学报（医学版）2026，Vol.47Issue(2)：224-228,5.DOI:10.12289/j.issn.2097-4345.25212
两种微刺激方案促排卵结局以及抑制黄体生成素峰效果的自身对照研究
A self-controlled study on the ovulation induction outcomes and the luteinizing hormone peak inhibition effects of two mild ovary stimulation
摘要
Abstract
Objective To compare the performance of two mild ovary stimulation(MOS)protocols in terms of ovulation induction outcomes and suppression of luteinizing hormone surges.Methods Ovulation induction was performed in the same cohort of patients using two different MOS protocols.The first ovulation induction cycle was conducted with the clomiphene citrate(CC)+human menopausal gonadotropin(HMG)protocol,which served as the control group.For the second ovulation induction cycle,the letrozole(LE)+HMG regimen was implemented,and when follicles reached a maximum diameter of 14 mm,CC(50 mg)was administered daily until the trigger day(denoted the LE+HMG+CC group).Results The numbers of retrieved eggs(3 vs 2,P=0.017),fertilized eggs(2 vs 1,P=0.033),and number of cleavages(2 vs 1,P=0.024)were significantly different between the control and LE+HMG+CC groups.The egg retrieval rate(68.10％vs 72.34％,P=0.396),proportion of metaphase Ⅱ eggs(80.70％vs 87.80％,P=0.348),proportion of excellent embryos on day 3(76.67％vs 87.50％,P=0.150),and proportion of usable eggs on day 3(55.05％vs 67.61％,P=0.093)showed an upward trend in the LE+HMG+CC group,although there was no statistical differences between the two groups.The proportion of multi-pronuclei zygotes showed a non-significant downward trend in the LE+HMG+CC group(9.6％vs 7.7％,P=0.652).Conclusion Both MOS regimens achieve similar clinical effectiveness,with good patient acceptance,and both effectively inhibit luteinizing hormone surges,these two protocols are worthy of promotion in clinical practice.关键词
微刺激/氯米芬/来曲唑/黄体生成素峰Key words
mild ovary stimulation/clomiphene citrate/letrozole/luteinizing hormone surge分类
医药卫生引用本文复制引用
洪岭,钱晨,徐奎,梁阿娟,唐传玲,赵美,阮井玲,杨万里,冯晓,郑锦霞..两种微刺激方案促排卵结局以及抑制黄体生成素峰效果的自身对照研究[J].同济大学学报（医学版）,2026,47(2):224-228,5.基金项目
上海市浦东新区科技发展基金事业单位民生科研专项项目(PKJ2023-Y58) （PKJ2023-Y58）
上海市"科技创新行动计划"自然科学基金项目(23ZR1450300) （23ZR1450300）
