药学研究2026，Vol.45Issue(4)：374-380,7.DOI:10.13506/j.cnki.jpr.2026.04.003
麻黄-桂枝水煎液对慢性脑缺血大鼠焦虑样行为及病理损伤的影响
Effects of Ephedra-Cinnamon Twig decoction on anxiety-like behavior and pathological damage in rats with chronic cerebral ischemia
摘要
Abstract
Objective To investigate the effects of Ephedra-Cinnamon Twig decoction on anxiety-like behavior and brain pathological damage in rats with chronic cerebral ischemia.Methods SD rats were randomly assigned to five groups:sham-operated,model,Ephedra(E),Cinnamon Twig(C),and Ephedra-Cinnamon Twig(EC),with 11 rats per group.After one week of oral administration(6 g·kg-1),bilateral common carotid artery occlusion was performed.On postoperative day 3,elevated plus maze and Y maze tests were conducted,and neuronal counts in cerebral cortex and hippocampus was assessed.Results Compared with the model group,the C and EC decoctions significantly increased open-arm time and entries in the elevated plus maze(P<0.05);The E and EC groups significantly improved spontaneous alternation rate in the Y-maze(P<0.05);Neuronal survival counts increased significantly in the hippocampal CA1 and DG regions in the C and EC groups(P<0.05);and in the cerebral cortex across all treatment groups(P<0.01),but no in hippocampal CA2 and CA3 regions.Conclusion Both Cinnamon Twig and Ephedra-Cinnamon Twig decoctions alleviate anxiety-like behavior in ischemic rats.Ephedra and its combination improve spatial memory,demonstrating neuroprotective effects specifically in hippocampal CA1,DG and cerebral cortex regions.关键词
麻黄-桂枝水煎液/慢性脑缺血大鼠/焦虑样行为/大脑/病理损伤Key words
Ephedra-Cinnamon Twig water decotion/Rats with chronic cerebral ischemia/Anxiety-like behaviors/Brain/Pathological injury分类
医药卫生引用本文复制引用
李一圣,陈飞瑜,许楷杭,邓小玉,卫平..麻黄-桂枝水煎液对慢性脑缺血大鼠焦虑样行为及病理损伤的影响[J].药学研究,2026,45(4):374-380,7.基金项目
深圳市科技计划项目基础研究面上项目(No.JCYJ20210324140204011) （No.JCYJ20210324140204011）
深圳市坪山区卫生健康系统科研项目(No.2023304) （No.2023304）
