生物加工过程2026，Vol.24Issue(2)：188-198,11.DOI:10.3969/j.issn.1672-3678.2026.02.009
蛋白冠的形成、调控及分析研究进展
Research progress on formation,control,and analytical techniques of protein coronas on nanoparticles
摘要
Abstract
Nanoparticles(NPs),upon introduction into a biological system,interact closely with macromolecules such as proteins present in the physiological environment,leading to the formation of a protein coronas(PC).Thereafter,the physicochemical properties of the nanoparticles are altered to some extent,resulting in the emergence of novel biological attributes.More importantly,the distribution,circulation time,ultimate fate,and toxicity of the particles are accordingly affected within the organism,thereby triggering various biological responses.Herein,we reviewed the recent progress on protein coronas,with focus on the factors influencing protein corona formation,as well as relevant analytical techniques and various controlling methods for protein coronas.In addition,we highlighted current research challenges and presented future directions for the design and advancement of nanoparticles.关键词
纳米颗粒/蛋白冠/相互作用Key words
protein corona/nanoparticles/interaction分类
生物科学引用本文复制引用
沈玉莹,程秀云,范明亮,郭栋,郑佳宇,吕宏旭,卢明夏..蛋白冠的形成、调控及分析研究进展[J].生物加工过程,2026,24(2):188-198,11.基金项目
中国科学院国际伙伴计划(030GJHZ2023098FN、030GJHZ2024103MI) （030GJHZ2023098FN、030GJHZ2024103MI）
