四川医学2026，Vol.47Issue(4)：383-387,5.DOI:10.16252/j.cnki.issn1004-0501-2026.04.005
成都某三甲骨科医院化脓性骨髓炎患者临床特征及预后分析
Analysis of Clinical Characteristics and Risk Factors of Patients with Suppurative Osteomyelitis in a Tertiary Ortho-pedic Hospital in Chengdu
刘小莉 1邹明 1王秦 1池继敏 1张静1
作者信息
- 1. 四川省骨科医院检验科,四川 成都 610041
- 折叠
摘要
Abstract
Objective To conduct a retrospective analysis on the clinical characteristics and prognosis of patients with suppurative osteomyelitis in a tertiary orthopedic hospital in Chengdu,including the infection sites,distribution of pathogenic bacte-ria,and infection indicators.Methods Clinical data,infection indicators,and bacterial culture results of patients with osteomyelitis admitted to Sichuan Provincial Orthopedic Hospital from July 2022 to December 2024 were collected.The distribution of infection sites,pathogenic bacteria,detection rate of multi-drug resistant bacteria,and differences in infection indicators among osteomyelitis patients were analyzed.According to the discharge conditions,the patients were divided into a good prognosis group and a poor prognosis group.Multivariate Logistic regression model was used to analyze the prognostic factors.Results The male to female ra-tio of 563 patients with suppurative osteomyelitis was 2.59∶1,the median age was 54(43,63)years.Tibia was the most common site of infection with 228 cases(40.50%).A total of 645 strains of pathogenic bacteria were isolated from 563 patients,and Staph-ylococcus aureus 285 strains(44.19%)was the most common.100 strains of methicillin-resistant Staphylococcus aureus(MRSA)and 10 strains of carbapenemase-producing bacteria(CRE)were detected.The serum levels of procalcitonin(PCT)and interleu-kin-6(IL-6)at admission were positively correlated with the length of stay(P＜0.05).Hospitalization days,PCT and IL-6 levels in the acute attack group were higher than those in the chronic group(P＜0.05).Multiple Logistic regression showed that acute and chronic osteomyelitis,PCT and IL-6 were prognostic factors of suppurative osteomyelitis.Conclusion Suppurative osteomyeli-tis is more common in men and occurs in tibia.Staphylococcus aureus is the most common pathogenic bacterium,and the detection rate of MRSA is relatively high.Acute or chronic osteomyelitis,inflammatory markers PCT and IL-6 are prognostic factors of suppu-rative osteomyelitis.关键词
骨髓炎/病原菌/耐药/危险因素Key words
osteomyelitis/pathogen/drug resistance/risk factors分类
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刘小莉,邹明,王秦,池继敏,张静..成都某三甲骨科医院化脓性骨髓炎患者临床特征及预后分析[J].四川医学,2026,47(4):383-387,5.
