陕西中医2026，Vol.47Issue(5)：625-629,5.DOI:10.3969/j.issn.1000-7369.2026.05.008
加味补气养血汤联合氨甲环酸对全膝关节置换术后气虚血瘀型患者隐性失血的影响
Modified Buqi Yangxue decoction combined with tranexamic acid reduces occult blood loss after total knee arthroplasty in patients with Qi-deficiency and blood-stasis pattern
摘要
Abstract
Objective:To explore effect of Modified Buqi Yangxue decoction combined with tranexamic acid on hidden blood loss in patients with Qi deficiency and blood stasis syndrome after total knee arthroplasty(TKA).Methods:Fifty-six patients with knee osteoarthritis undergoing unilateral TKA were randomly divided into two groups(n=28).The control group were intravenously infused with tranexamic acid during the operation.The treat-ment group were given modified Buqi Yangxue decoction in addition to the control group during the perioperative pe-riod.The TCM symptom scores,visual analogue scale(VAS)for pain,HSS score of the knee joint,and changes in hemoglobin(Hb)and hematocrit(Hct)were compared between the two groups.The blood loss was calculated and complications were observed.Results:The postoperative drainage volume,hidden blood loss volume and total blood loss volume in the treatment group were all lower than those in the control group(P<0.05).There was no statisti-cally significant difference in intraoperative blood loss between the two groups(P>0.05).There was no statistically significant difference in TCM syndrome scores between the two groups on the first day after surgery(P>0.05).The TCM syndrome scores in the treatment group were lower than those in the control group on the 7th and 14th days af-ter surgery(P<0.05).The HSS scores of both groups were higher than those before surgery after surgery,and the treatment group was higher than the control group(P<0.05).There was no statistically significant difference in VAS scores between the two groups at each time point before and after surgery(P>0.05).The levels of Hb and Hct in the treatment group were higher than those in the control group on the 7th and 14th days after surgery(P<0.05),and there was no statistically significant difference on the 3rd day after surgery(P>0.05).Neither group re-ceived allogeneic blood transfusion or had serious complications.Conclusion:Modified Buqi Yangxue decoction com-bined with tranexamic acid can reduce hidden blood loss after TKA,stabilize Hb and Hct levels,improve TCM syndrome and promote the recovery of knee joint function,and is a safe and effective perioperative adjuvant treatment plan.关键词
膝骨性关节炎/全膝关节置换术/加味补气养血汤/氨甲环酸/隐性失血量/膝关节功能Key words
Knee osteoarthritis/Total knee arthroplasty/Modified Buqi Yangxue decoction/Tranexamic acid/Hidden blood loss/Knee function分类
医药卫生引用本文复制引用
刘昕岩,程韶,王吉利,李基威,班赛博,郑博文,许文龙,王上增..加味补气养血汤联合氨甲环酸对全膝关节置换术后气虚血瘀型患者隐性失血的影响[J].陕西中医,2026,47(5):625-629,5.基金项目
河南省自然科学基金资助项目(232300420269,222300420486) （232300420269,222300420486）
河南省科技攻关项目(252102310454) （252102310454）
河南省高校科技创新团队(24IRTSTHN040) （24IRTSTHN040）
河南省中青年卫生健康科技创新领军人才培养项目(LJRC2024020) （LJRC2024020）
河南省中医药科学研究专项课题(2021ZY2010,2019ZY2035) （2021ZY2010,2019ZY2035）
郑州市科技惠民计划项目(2023KJHM0009) （2023KJHM0009）
