陕西中医2026，Vol.47Issue(5)：635-640,646,7.DOI:10.3969/j.issn.1000-7369.2026.05.010
黄蜀葵花制剂联合指南导向药物治疗心肌梗死后心力衰竭临床研究
Clinical research on Abelmoschus manihot combined with guideline-directed medical therapy in post-myocardial infarction heart failure
摘要
Abstract
Objective:To observe clinical efficacy of the combination of Abelmoschus manihot preparation(Ji-ahua tablets)and guideline-directed medical therapy(GDMT)in patients with heart failure(HF)after myocardial infarction(MI).Methods:A total of 65 patients with heart failure after myocardial infarction were selected for the study and randomly divided into an observation group(30 cases)and a control group(35 cases)using a random number table.The control group was treated with GDMT,while the observation group was treated with Jiahua tab-lets in addition to GDMT.The TCM syndrome scores,serum N-terminal pro-B-type natriuretic peptide(NT-proB-NP),cardiac troponin I(cTnI),soluble suppression of tumorigenicity 2(sST2),interleukin-6(IL-6),and total su-peroxide dismutase(T-SOD)levels were observed and compared before and 7 days after treatment in both groups to evaluate the clinical efficacy.Results:After treatment,the TCM syndrome scores and serum NT-proBNP,cTnI,and IL-6 levels in the observation group were significantly lower than those before treatment(P<0.01),and the serum T-SOD level was significantly higher than that before treatment(P<0.01).However,there were no statistically significant differences in the above indicators before and after treatment in the control group(P>0.05).Regarding the serum sST2 level,it remained stable in the observation group before and after treatment(P>0.05),while it was significantly higher in the control group after treatment compared with before treatment(P<0.05).Inter-group comparison showed that the observation group had significantly better control of all indicators after treatment than the control group(P<0.05).Conclusion:In addition to GDMT,the combination of Jiahua Tablets can significantly improve the TCM syndrome of patients with heart failure after myocardial infarction,reduce myocardial injury,inhib-it the levels of sST2 and inflammatory factors in the acute phase,enhance antioxidant capacity,and has positive sig-nificance in improving microenvironment related to early ventricular remodeling.关键词
心肌梗死后心力衰竭/黄蜀葵花/甲花片/可溶性生长刺激表达基因 2 蛋白/心室重构/炎症因子Key words
Post-myocardial infarction heart failure/Abelmoschus manihot/Jiahua tablets/Soluble suppres-sion of tumorigenicity 2/Ventricular remodeling/Inflammatory factor分类
医药卫生引用本文复制引用
王小龙,贾琪,林欣,牛茹歌,杨文莉,包桐,王令谆..黄蜀葵花制剂联合指南导向药物治疗心肌梗死后心力衰竭临床研究[J].陕西中医,2026,47(5):635-640,646,7.基金项目
江苏省中医药科技发展计划项目(YB2020007) （YB2020007）
江苏省中医临床医学创新中心项目(苏中医科技函[2023]1号) （苏中医科技函[2023]1号）
