中草药2026，Vol.57Issue(8)：3189-3195,7.DOI:10.7501/j.issn.0253-2670.2026.08.029
"黜浊培本"理论指导中医药治疗前列腺癌的研究进展
Research progress on treatment of prostate cancer with traditional Chinese medicine guided by"Chuzhuo Peiben"theory
摘要
Abstract
"Chuzhuo Peiben"theory,proposed by nationally renowned Chinese medicine expert Professor Jia Yingjie,plays an important role in guiding the treatment of prostate cancer with traditional Chinese medicine.This article reviews the theory from the perspectives of theoretical interpretation,evidence integration,and paradigm construction.It systematically elucidates the dynamic pathogenesis model of"deficiency of the primordial foundation-coagulation of cancerous turbidity"and demonstrates the core logic of the strategy"tonifying the spleen surpasses tonifying the kidney"in circumventing androgen-related risks and remodeling the tumor microenvironment.In terms of clinical practice,it analyzes the staging-based dynamic treatment system centered around the"Jianpi Lishi Huayu Formula"and evaluates its synergistic value in combined therapy for"enhancing efficacy and reducing toxicity"and"delaying drug resistance."At the mechanistic level,it integrates multidisciplinary evidence to construct a stereoscopic action network that spans from"multi-target synergistic prediction"to"core pathway experimental validation"and further to"tumor immune microenvironment remodeling,"thereby clarifying the biological basis of integrative intervention.The review also summarizes three core paradigmatic values of TCM intervention.In response to current research challenges,it proposes strategies such as designing prospective platform trials,applying multi-omics technologies,and constructing TCM-specific core outcome sets to promote the development of this field toward evidence-based and precision medicine paradigms.关键词
前列腺癌/黜浊培本/健脾利湿化瘀方/从脾论治/整合医学Key words
prostate cancer/Chuzhuo Peiben/Jianpi Lishi Huayu Formula/treatment based on spleen theory/integrative medicine分类
医药卫生引用本文复制引用
牟睿宇,马铭泽,杨佩颖,朱津丽,贾英杰.."黜浊培本"理论指导中医药治疗前列腺癌的研究进展[J].中草药,2026,57(8):3189-3195,7.基金项目
天津中医药大学第一附属医院科研基金项目(院XB2024007) （院XB2024007）
天津市卫健委项目(2025050) （2025050）
