中草药2026，Vol.57Issue(8)：3210-3222,13.DOI:10.7501/j.issn.0253-2670.2026.08.031
芦荟大黄素抗肿瘤的多靶点机制与转化策略研究进展
Research progress on multi-target mechanisms and translational strategies of aloe-emodin in antitumor therapy
摘要
Abstract
Malignant tumors remain the leading cause of death in China.Their pathogenesis and progression involve multifaceted mechanisms,including genetic mutations,aberrant activation of signaling pathways,and dysregulation of the tumor microenvironment.Current clinical management continues to face significant challenges,such as chemotherapy resistance and the limited efficacy of targeted therapies.Aloe-emodin(AE),a primary anthraquinone active constituent found in the traditional medicinal plant Aloe,demonstrates a promising multi-targeted and multi-mechanistic profile as an anti-tumor agent.This review systematically elucidates the antitumor mechanisms and related research progress of AE,specifically highlighting the induction of autophagy via inhibition of the protein kinase B(Akt)/mammalian target of rapamycin(mTOR)axis,the promotion of apoptosis through activation of mitochondrial pathways,the suppression of invasion and metastasis by downregulating matrix metalloproteinases(MMPs),and the enhancement of antitumor activity via modulation of the tumor immune microenvironment.Additionally,AE enhances antitumor activity by modulating the immune microenvironment.Furthermore,the therapeutic potential of AE is validated through structural optimization and drug combination strategies.This review highlights recent advances in understanding the molecular mechanisms of AE and anticipates its clinical translation,aiming to provide a theoretical basis for cancer therapy and inform the development of novel treatment modalities.关键词
芦荟大黄素/抗肿瘤/诱导凋亡/蛋白激酶B/哺乳动物雷帕霉素/结构改造/联合治疗Key words
aloe-emodin/antitumor activity/apoptosis/Akt/mTOR/structural modification/combination therapy分类
医药卫生引用本文复制引用
吉燕华,刘朝煌,马晓雪,张思源,邹艺鹏,黄荣婷,曾治君..芦荟大黄素抗肿瘤的多靶点机制与转化策略研究进展[J].中草药,2026,57(8):3210-3222,13.基金项目
国家自然科学基金项目(82460801,82460857) （82460801,82460857）
江西中医药大学校级科技创新团队发展计划项目(CXTD22007) （CXTD22007）
江西中医药大学省级大学生创新创业计划(S202510412084) （S202510412084）
