眼科学报2026，Vol.41Issue(4)：275-283,9.DOI:10.12419/25071001
中国大陆地区青光眼致盲负担趋势:1990-2021年
Trends in glaucoma-related blindness burden in the Chinese mainland,1990-2021
摘要
Abstract
Objective:Glaucoma is the leading cause of irreversible blindness worldwide.This study aimed to use the Global Burden of Disease(GBD)2021 database to analyze the epidemiological patterns of glaucoma-related blindness in the Chinese mainland from 1990 to 2021,providing evidence for the development of blindness prevention strategies.Methods:Data on glaucoma-related blindness and demographics information from the Chinese mainland were extracted from the GBD 2021 database.Joinpoint regression analysis was used to evaluate the temporal trends in the burden of glaucoma-related blindness.This was achieved by calculating the annual percentage change(APC),the average annual percentage change(AAPC),and their corresponding 95%confidence intervals(CI).Additionally,the age-period-cohort model was employed to assess the impacts of age,period,and cohort on the burden of blindness.This was done by calculating net drift,local drift,period relative risk,cohort relative risk,and fitted longitudinal age curves.Results:Between 1990 and 2021,the total number of cases of glaucoma-related blindness in the Chinese mainland increased.However,the prevalence rate of blindness decreased significantly,dropping from 56.83 cases per 100,000 population(uncertainty interval[UI]:45.93 to 69.96)in 1990 to 23.32 cases per 100,000 population(UI:18.46 to 28.84)in 2021,with an AAPC of-2.63(95%CI:-2.75 to-2.50,P<0.001).The burden of glaucoma-related blindness was higher among males than among females,but the decline in the prevalence of blindness was more marked in males.The risk of glaucoma-related blindness increased substantially with age,while risks associated with the period and cohort showed a decreasing trend.Conclusions:Since 1990,the burden of glaucoma-related blindness in the Chinese mainland has witnessed a significant reduction,which reflects the success of blindness prevention efforts.Continuously optimizing comprehensive strategies for eye health management is crucial to further reduce the incidence of blindness associated with glaucoma.关键词
青光眼/疾病负担/全球疾病负担/年龄-时期-队列模型/时间趋势Key words
glaucoma/disease burden/global burden of disease/age-period-cohort model/time trends分类
医药卫生引用本文复制引用
肖悦,陈健祺,卓业鸿,朱颖婷..中国大陆地区青光眼致盲负担趋势:1990-2021年[J].眼科学报,2026,41(4):275-283,9.基金项目
国家自然科学基金(82471074) （82471074）
广东省基础与应用基础研究基金(2024A1515013058) （2024A1515013058）
广东省高等学校重大致盲眼病防治基础研究卓越中心(2024-PIZC-022).This work was supported by the National Natural Science Foundation of China(82471074),Guangdong Basic and Applied Basic Research Foundation(2024A1515013058),and the Guangdong Basic Research Center of Excellence for Major Blinding Eye Diseases Prevention and Treatment(2024-PIZC-022). （2024-PIZC-022）
