癌症神经科学视角下肺癌演进的神经调控机制与临床治疗挑战
Neuroregulatory Mechanisms of Lung Cancer Progression and Clinical Treatment Challenges from the Perspective of Cancer Neuroscience
摘要
Abstract
Lung cancer is the leading cause of cancer morbidity and mortality worldwide.A highly complex bidirec-tional regulatory relationship exists between lung cancer progression and the nervous system.The nervous system is believed to play a pivotal regulatory role in the genesis of lung cancer.It is involved in regulating malignant biological behaviors such as proliferation,local invasion,and distant metastasis of lung cancer cells via core mediating pathways involving neurons,neu-rotransmitters,and neuroactive molecules.At the same time,lung cancer itself and related therapeutic interventions are capable of inducing reverse structural and functional reprogramming within the nervous system.The emergence of cancer neuroscience as a novel interdisciplinary field offers a new perspective to overcome the current bottlenecks in lung cancer treatment,yet it also faces numerous theoretical and clinical challenges that urgently require resolution.This article systematically reviews the intricate relationship between the nervous system and lung cancer progression,focusing on the potential effects and molecular mechanisms of clinical strategies including local therapies,chemotherapy,immunotherapy,and targeted therapy on the nervous system,with the aim of clarifying research opportunities and key challenges in this field and providing a theoretical foundation and practical reference for optimizing the precision treatment system of lung cancer and improving clinical efficacy.关键词
肺肿瘤/癌症神经科学/神经系统/神经活性分子Key words
Lung neoplasms/Neuroscience/Neuro-oncology/Neuroactive molecule引用本文复制引用
王娜,张波,尚立涵,王雪瑞,王小杉,范琪钰,王超然,孔凡铭..癌症神经科学视角下肺癌演进的神经调控机制与临床治疗挑战[J].中国肺癌杂志,2026,29(3):208-220,13.基金项目
This paper was supported by the grants from Noncommunicable Chronic Diseases-National Science and Technology Major Project(No.2024ZD0521103,to Fanming KONG),Science and Technology Project of Haihe Laboratory of Modern Chinese Medicine(No.GZY-KJS-2025-056,to Fanming KONG),and Tianjin Public Health Science and Technology Major Youth Project(No.24ZXGQSY00090,to Fanming KONG),Pilot Demonstration Project for the Inheritance and Innovative Development of Traditional Chinese Medicine in Nankai District, Tianjin (No.20240204020, to Chaoran WANG) and First Teaching Hospital of Tianjin University of Traditional Chinese Medicine "Tuoxin Project" (No.2023008, to Chaoran WANG).本文受四大慢病重大专项(No.2024ZD0521103)、现代中医药海河实验室科技项目(No.GZY-KJS-2025-056)、天津市公共卫生科技重大专项青年项目(No.24ZXGQSY00090)、天津市南开区中医药传承创新发展示范试点项目(No.20240204020)及天津中医药大学第一附属医院"拓新工程"基金科研课题(No.2023008)资助 （No.2024ZD0521103,to Fanming KONG）
