中国肺癌杂志2026，Vol.29Issue(3)：221-228,8.DOI:10.3779/j.issn.1009-3419.2026.101.06
阻塞性睡眠呼吸暂停合并肺癌的研究进展
Research Advances in Obstructive Sleep Apnea and Lung Cancer Comorbidity
摘要
Abstract
Obstructive sleep apnea(OSA)is a common sleep-related breathing disorder characterized by recurrent upper airway collapse and apnea during sleep,resulting in intermittent hypoxia,oxidative stress,and systemic inflammation,and is closely associated with multisystem dysfunction,including cardiovascular disease,cognitive impairment,and metabolic abnormalities.Lung cancer remains one of the leading causes of cancer-related mortality worldwide and represents a major threat to human health.Recent studies suggest that OSA and lung cancer share several common risk factors,including smok-ing,older age,and obesity,and exhibit overlapping pathophysiological mechanisms,indicating that OSA may be involved in the initiation and progression of lung cancer.However,the epidemiological evidence regarding the association between OSA and lung cancer remains inconsistent,and the underlying molecular mechanisms as well as the clinical value of potential interven-tions have yet to be systematically elucidated.This review therefore summarizes the epidemiological characteristics,potential pathophysiological mechanisms,and therapeutic strategies related to the coexistence of OSA and lung cancer,with the aim of providing a theoretical basis for clinical decision-making and future mechanistic studies.关键词
阻塞性睡眠呼吸暂停/肺肿瘤/慢性间歇性低氧/病理生理机制/流行病学Key words
Obstructive sleep apnea/Lung neoplasms/Chronic intermittent hypoxia/Pathophysiological mecha-nism/Epidemiology引用本文复制引用
曹赫,杨姗姗,孙文佳,周建娅..阻塞性睡眠呼吸暂停合并肺癌的研究进展[J].中国肺癌杂志,2026,29(3):221-228,8.基金项目
This paper was supported by the grant from the Zhejiang Provincial Key Research and Development Program for Respiratory Diseases(No.2023C03069,to Jianya ZHOU). 本文受浙江省呼吸系统疾病重点研发计划项目(No.2023C03069)资助 （No.2023C03069,to Jianya ZHOU）
