中草药2026，Vol.57Issue(7)：2463-2468,6.DOI:10.7501/j.issn.0253-2670.2026.07.003
鬼箭羽化学成分研究
Chemical composition of Euonymus alatus
摘要
Abstract
Objective To investigate the chemical constituents of Euonymus alatus.Methods Separation and purification were performed using normal-and reversed-phase silica gel,Sephadex LH-20,and high-performance liquid chromatography.The structures of the obtained compounds were identified using NMR,MS,and X-Ray techniques.The protective effect of the compound against podocyte injury was evaluated using the CCK-8 assay.Results Six compounds were isolated and purified from the dichloromethane fraction of the 95％ethanol extract of E.alatus,namely 3β-hydroxy-24-norhopa-4(23)(1),acetyl ursolic acid(2),betulinic acid(3),foliasalaci A4(4),betulonicacid(5),and ursolic acid lactone(6).Moreover,compound 1 has a significant protective effect against MPC5 cell damage induced by advanced glycation end-products(AGEs).Conclusion Compound 1 is a new compound,named 2,4-dehydrowhite birch resinol.All the other compounds were isolated from this plant and plants of the same genus.Compound 1 exhibits anti-podocyte injury activity in a concentration-dependent manner.关键词
鬼箭羽/三萜化合物/白桦脂醇/足细胞/MPC5细胞/2,4-降白桦脂醇/乙酰乌索酸/白桦脂酮酸Key words
Epimedium alatus(Thunb.)Siebold/triterpenoid/betulin/podocytes/MPC5 cells/2,4-dehydrowhite birch resinol/acetyl ursolic acid/betulonicacid分类
医药卫生引用本文复制引用
王奕航,杜雨璇,郭鑫鑫,张效威,薛贵民,王潘,徐江雁..鬼箭羽化学成分研究[J].中草药,2026,57(7):2463-2468,6.基金项目
国家重点研发计划资助项目(2020YFE0201800) （2020YFE0201800）
国家自然科学基金面上项目(82474495) （82474495）
河南省高校科技创新人才(24HASTIT072) （24HASTIT072）
