中草药2026，Vol.57Issue(7)：2493-2500,8.DOI:10.7501/j.issn.0253-2670.2026.07.006
基于AHP-熵权法结合Box-Behnken设计-响应面法优选大青叶㕮咀饮片压制工艺
Compression process optimization of Isatidis Folium Fujv decoction pieces with AHP-entropy weighting and Box-Behnken design-response surface methodoloy
摘要
Abstract
Objective To establish the pressing process of the Fujv decoction pieces of Daqingye(Jsatidis Folium,IF),and determine the optimal process parameters.Methods The contents of indirubin,isovitexin and tryptanthrin in IF were determined by HPLC.The paste yield was determined by hot maceration.The analytic hierarchy process(AHP)-entropy weight method was used to determine the weight coefficients of each index and calculate the comprehensive score.Pressure,compression time,drying temperature and drying time were investigated as single factors.The AHP-entropy weight method combined with the Box-Behnken design-response surface methodoly(BBD-RSM)was used to optimize the pressing process of the decoction pieces of the Fujv decoction pieces of IF.Results The optimal parameters of the initial pressing process of the decoction pieces of the Fujv decoction pieces are as follows:After moistening,the medicinal materials were cut into 5-7 mm pieces,pressed at 4 MPa for 60 s,and baked at 60℃ for 4 h.Under these conditions,the overall desirability(OD)value of the validation tests was 94.12％,which is close to the predicted OD value of 93.30％.Conclusion The compression process for IF Fujv decoction pieces is practically feasible,providing a reference for the development and utilization of such pieces.关键词
大青叶/㕮咀/Box-Behnken设计-响应面法/AHP-熵权法/压制工艺/靛玉红/异牡荆素/色胺酮Key words
Isatidis Folium/Fujv decoction pieces/Box-Behnken design-response surface methodoloy/AHP-entropy weight method/pressing process/indirubin/isovitexin/tryptanthrin分类
医药卫生引用本文复制引用
刘仟禧,李红伟,郭志俊,李凯..基于AHP-熵权法结合Box-Behnken设计-响应面法优选大青叶㕮咀饮片压制工艺[J].中草药,2026,57(7):2493-2500,8.基金项目
国家自然科学基金面上项目(82474099) （82474099）
河南省杰出青年基金项目(252300421028) （252300421028）
河南省高校科技创新团队(26IRTSTHN018) （26IRTSTHN018）
