中风与神经疾病杂志2026，Vol.43Issue(4)：303-308,6.DOI:10.19845/j.cnki.zfysjjbzz.2026.0052
基于多导睡眠图与神经心理测验:慢性失眠症患者执行功能损害的特征及其相关因素研究
Characteristics of executive function impairment and related factors in patients with chronic insomnia disorder:A study based on polysomnography and neuropsychological tests
摘要
Abstract
Objective To investigate the characteristics of executive function impairment in patients with chronic insomnia disorder and its correlation with objective sleep structure parameters.Methods A total of 92 patients who met the DSM-5 diagnostic criteria for chronic insomnia disorder were enrolled as chronic insomnia disorder group,and 45 healthy controls were enrolled as healthy control group.All subjects underwent assessments for anxiety and depression,overnight polysomnography,and executive function,and the two groups were compared in terms of sleep parameters(in-cluding sleep latency,sleep efficiency,total sleep time,sleep stages,and the proportion of each stage)and executive function(Stroop Color-Word Test,digit span test,and trail making test),as well as the correlation between these param-eters.Results Compared with the healthy control group,the chronic insomnia disorder group had significant increases in Stroop Card C completion time,Stroop interference effect,trail making test-B completion time,and trail making test B-A time difference and significant reductions in the score of digit span backward task and the total score of digit span test(P<0.05).The correlation analysis showed that total sleep time,sleep efficiency,NREM stage 3 duration,and the proportion of NREM stage 3 were negatively correlated with Stroop Card C completion time,Stroop interference effect,trail making test-B completion time,and trail making test B-A time difference and were positively correlated with the score of digit span backward task and the total score of digit span test(P<0.05).Conversely,NREM stage 1 duration and the proportion of NREM stage 1 were positively correlated with Stroop Card C completion time,Stroop interference effect,trail making test-B completion time,and trail making test B-A time difference and were negatively correlated with the score of digit span backward task(P<0.05).Conclusion Patients with chronic insomnia disorder exhibit executive function impairment in multiple dimensions including inhibitory control,working memory,and cognitive flexibility,which are associated with the reductions in sleep efficiency and deep sleep.关键词
慢性失眠症/执行功能/抑制控制/工作记忆/认知灵活性Key words
Chronic insomnia disorder/Executive function/Inhibitory control/Working memory/Cogni-tive flexibility分类
医药卫生引用本文复制引用
叶圆圆,龙诗琦,陶敏,冉艳琼,李文涛,蒋晓江..基于多导睡眠图与神经心理测验:慢性失眠症患者执行功能损害的特征及其相关因素研究[J].中风与神经疾病杂志,2026,43(4):303-308,6.基金项目
上海医学创新发展基金会项目"中西医结合卒中中心建设"(WL-CZZX-2022001K) （WL-CZZX-2022001K）
