摘要
Abstract
Objective To investigate the serum markers for rapid eye movement sleep behavior disorder(RBD)in patients with Parkinson disease(PD)and their predictive value.Methods A total of 132 PD patients who were admitted to Fuxing Hospital,Capital Medical University,from January 2020 to December 2023 were enrolled as subjects,and ac-cording to the presence or absence of RBD,they were divided into RBD group with 47 patients and non-RBD group with 85 patients.The two groups were compared in terms of general information and the serum levels of neurofilaments(NFL),glial fibrillary acidic protein(GFAP),lipoprotein-associated phospholipase A2(Lp-PLA2),neurotrophic factor-3(NT-3),and homocysteine(Hcy).Univariate and multivariate logistic regression analyses were used to investigate inde-pendent risk factors for RBD in PD patients,and the receiver operating characteristic(ROC)curve was used to assess their predictive value.Results Compared with the non-RBD group,the RBD group had significantly higher serum levels of NFL,GFAP,Lp-PLA2,and Hcy(P<0.05)and a significantly lower serum level of NT-3(P<0.05).Serum GFAP(95%CI 0.387‒0.847,P=0.005),Lp-PLA2(95%CI 0.859‒0.947,P=0.005),NT-3(95%CI 1.033‒1.180,P=0.003),and Hcy(95%CI 0.259‒0.655,P<0.001)were significant risk factors for RBD in PD patients.The ROC curve analysis showed that GFAP(AUC=0.767),Lp-PLA2(AUC=0.845),NT-3(AUC=0.829),and Hcy(AUC=0.888)used alone had a good predictive ability,while the combined model of these four indicators had the strongest predictive ability(AUC=0.982),followed by Lp-PLA2+Hcy(AUC=0.944)and GFAP+Hcy(AUC=0.928).Conclusion Serum GFAP,Lp-PLA2,NT-3,and Hcy are significant risk factors for RBD in PD patients and have a good predictive value.The combined model of these four indicators has the strongest predictive ability,suggesting that combined measurement of these indica-tors can be used for early warning of the risk of RBD in PD patients.关键词
帕金森病/快速眼动睡眠行为障碍/神经丝蛋白轻链/胶质纤维酸性蛋白/脂蛋白磷脂酶A2/神经营养因子-3/同型半胱氨酸/预测价值Key words
Parkinson's disease/Rapid eye movement sleep behavior disorder/Neurofilaments/Glial fibrillary acidic protein/Lipoprotein-associated phospholipase A2/Neurotrophic factor-3/Homocysteine/Predictive value分类
医药卫生
