中风与神经疾病杂志2026，Vol.43Issue(4)：343-348,6.DOI:10.19845/j.cnki.zfysjjbzz.2026.0059
不同频率重复经颅磁刺激治疗多系统萎缩的临床疗效研究
Clinical efficacy of repetitive transcranial magnetic stimulation at different frequencies in the treatment of multiple system atrophy
摘要
Abstract
Objective To identify the effective therapeutic targets of multiple system atrophy-parkinsonian type(MSA-P)based on clinical and electrophysiological assessment indices,and to investigate the clinical efficacy of low-frequency versus high-frequency repetitive transcranial magnetic stimulation(rTMS)applied to the primary motor cortex(M1 region)of the brain in patients with MSA-P.Methods A total of 40 patients with MSA-P who were diagnosed and treated in Jilin People's Hospital from January 2023 to December 2024 were enrolled,and according to the frequency of rTMS,they were divided into low-frequency group with 20 patients and high-frequency group with 20 patients.The pa-tients in the low-frequency group received 1 Hz rTMS over the M1 region,while those in the high-frequency group received 5 Hz rTMS over the M1 region,and clinical and electrophysiological assessments were performed for both groups at 1 week,2 weeks,4 weeks,and 3 months after intervention.Results After low-frequency or high-frequency rTMS was applied to the M1 region of MSA-P patients,there were no significant improvements in clinical and electrophysiological as-sessment indices in the low-frequency group,while the high-frequency group had significant improvements in clinical and electrophysiological assessment indices.Conclusion The primary motor cortex(M1 region)of the brain is an effective therapeutic target for MSA-P.Excitatory stimulation of the M1 region significantly improves the clinical and electrophysi-ological assessment indices of MSA-P,while inhibitory stimulation of the M1 region fails to achieve such improvements.This study shows that rTMS is an effective therapeutic modality for MSA-P and thus holds promise for clinical application.High-frequency rTMS over the M1 region can improve the symptoms of MSA-P and correct abnormal rhythmic activity within the cortex and related subcortical brain regions,thereby achieving a sustained therapeutic effect.关键词
多系统萎缩/重复经颅磁刺激/初级运动皮质/大脑M1区Key words
Multiple system atrophy/Repetitive transcranial magnetic stimulation/Primary motor cortex/M1 region分类
医药卫生引用本文复制引用
郭俊猛,唐勇,王勇..不同频率重复经颅磁刺激治疗多系统萎缩的临床疗效研究[J].中风与神经疾病杂志,2026,43(4):343-348,6.基金项目
吉林市科技创新发展计划项目(20230406152) （20230406152）
