中风与神经疾病杂志2026，Vol.43Issue(4)：349-355,7.DOI:10.19845/j.cnki.zfysjjbzz.2026.0060
血清瘦素与帕金森病关系的Meta分析研究
Association between serum leptin and Parkinson disease:A meta-analysis
摘要
Abstract
Objective Many studies in recent years have shown that leptin may exert a protective effect on neurons in patients with Parkinson disease(PD),but related research findings remain inconsistent.Therefore,this article system-atically reviews the role of leptin in PD patients through a meta-analysis.Methods PubMed,Embase,ISI Web of Sci-ence,and CNKI were searched for related articles published up to March 2020.In order to assess the overall effect,the fixed effects model was used to calculate pooled effect size,standardized mean difference(SMD),and 95%confidence in-terval(CI).Subgroup analysis,sensitivity analysis,and publication bias analysis were performed to assess the stability and reliability of the studies included in the meta-analysis.Results A total of 7 studies were included in the meta-analysis according to strict inclusion criteria,involving 167 PD patients and 141 healthy controls.The results showed that the PD patients had a significantly lower serum level of leptin than the healthy controls(SMD=-0.328,95%CI-0.560 to-0.096,P=0.006).The subgroup analysis showed that Caucasian PD patients had a relatively low serum level of leptin(SMD=-0.301,95%CI-0.566 to-0.036,P=0.026),while there was no significant difference in the serum level of leptin among Asian patients(SMD=-0.414,95%CI-0.891 to 0.063,P=0.089).The sensitivity analysis showed the stability of overall effect size.The funnel plots showed no significant asymmetry,and no obvious publication bias was ob-served by the Begg test.Conclusion This meta-analysis shows that PD patients have a lower serum level of leptin than the healthy population,suggesting that serum leptin might be involved in the pathological process of PD,and further stud-ies are needed to clarify the specific mechanism.关键词
瘦素/帕金森病/血清/脂肪细胞因子Key words
Leptin/Parkinson disease/Serum/Adipokine分类
医药卫生引用本文复制引用
谭臣臣,郭晓宁,赵宝华,张薛..血清瘦素与帕金森病关系的Meta分析研究[J].中风与神经疾病杂志,2026,43(4):349-355,7.基金项目
国家自然科学基金(81971192) （81971192）
青岛市自然科学基金(23-2-1-130-zyyd-jch) （23-2-1-130-zyyd-jch）
青岛市医药卫生科研计划项目(2022-WJZD056) （2022-WJZD056）
山东省医药卫生科技项目(202503071090) （202503071090）
