摘要
Abstract
Objective To analyze the drug resistance characteristics of Escherichia coli in patients with perianal abscess of heat-toxin exuberance syndrome,and to provide a basis for rational clinical medication.Methods A total of 108 patients with perianal abscess of heat-toxin exuberance syndrome admitted to Zhengzhou Hospital of Coloproctological Diseases from July 2025 to January 2026 were enrolled as the research objects.Pus samples were collected from patients for pathogen isolation,identification and drug sensitivity test,and drug resistance gene detection was performed on the isolated Escherichia coli.The pathogen distribution and drug resistance characteristics of Escherichia coli in such patients were statistically analyzed.Results Among the 108 pus samples,97 were positive for bacterial culture(89.81%).A total of 99 bacterial strains were detected in the positive samples,including 60 strains of Escherichia coli(60.61%),27 strains of Klebsiella pneumoniae(27.27%),6 strains of Proteus mirabilis(6.06%),2 strains of Klebsiella ornithinolytica(2.02%),1 strain of Klebsiella oxytoca(1.01%),1 strain of Enterobacter agglomerans(1.01%),1 strain of Staphylococcus aureus(1.01%),and 1 strain of Staphylococcus epidermidis(1.01%).Escherichia coli was the main patho-genic bacterium.Further drug sensitivity test and drug resistance gene detection showed that the bacterium had high drug resistance rates to ampicillin(78.33%),trimethoprim-sulfamethoxazole(56.67%),cefazolin(43.33%),cefuroxime(38.33%),ceftriaxone(33.33%),ciprofloxacin(33.33%),levofloxacin(31.67%),and gentamicin(26.67%).The detection rates of drug resistance genes were as follows:98.33%(59/60)for the gyrA gene,96.67%(58/60)for the gyrB gene,6.67%(4/60)for the parC gene,61.67%(37/60)for the TEM gene,and 1.67%(1/60)for the VIM gene.Conclusion The main pathogenic bacterium in patients with perianal abscess of heat-toxin exuberance syndrome is Escherichia coli,which has high drug resis-tance to a variety of commonly used antibiotics.Enzyme inhibitor-containing compound preparations or carbap-enem antibiotics can be preferred for clinical treatment.关键词
肛周脓肿/热毒炽盛/大肠埃希菌/耐药性分析/耐药基因Key words
Perianal abscess/Heat-toxin exuberance syndrome/Escherichia coli/Drug resistance analysis/Drug resistance gene
