新中医2026，Vol.58Issue(9)：157-167,11.DOI:10.13457/j.cnki.jncm.2026.09.024
基于网络药理学和分子对接技术分析黄连解毒汤异病同治阿尔茨海默病和癫痫的作用机制
Analysis on Mechanism of Treating Different Diseases with the Same Therapy via Huanglian Jiedu Decoction for Alzheimer's Disease and Epilepsy Based on Network Pharmacology and Molecular Docking Technology
摘要
Abstract
Objective:To analyze the mechanism of Huanglian Jiedu Decoction in treating Alzheimer's disease(AD)and Epilepsy(EP)using network pharmacology and molecular docking technology.Methods:Active ingredients and corresponding targets of Huanglian Jiedu Decoction were predicted from TCMSP,BATMAN,ETCM,HERB,SYMMAP,and TCMID;disease targets for AD and EP were retrieved from GeneCards,CTD,and OpenTargets;overlapping targets were screened via STRING and Cytoscape and received visual analysis.GO and KEGG enrichment analyses were performed using R Language to construct"active ingredient-overlapping target-pathway"network;molecular docking was verified using AutoDock Tools.Results:A total of 132 active ingredients,1 439 drug targets,229 disease targets related to AD and EP,and 152 overlapping targets were identified.Network pharmacology screening revealed five primary active ingredients:quercetin,berberine,wogonin,baicalein,and baicalin.Core targets were TP53,JUN,AKT1,IL-6,and TNF,etc.GO function enrichment analysis revealed 2 231 BP,85 CC and 147 MF terms;KEGG identified 192 pathways,including TNF,lipids and advanced glycation end products and their receptors(AGE-RAGE)in atherosclerosis and diabetic complications;the results of molecular docking showed that the binding energy of the main active ingredients and the core target molecules was lower than-5.0 kcal/mol,indicating strong binding affinity.Conclusion:Through quercetin,berberine,wogonin,baicalein,and baicalin,Huanglian Jiedu Decoction can act on targets such as TP53,JUN,AKT1,IL-6,and TNF,regulate the pathways of AGE-RAGE,TNF,and lipid and atherosclerosis in diabetic complications,so as to play the role of treating AD and EP with the same therapy.关键词
黄连解毒汤/异病同治/阿尔茨海默病/癫痫/网络药理学/分子对接Key words
Huanglian Jiedu Decoction/Treating different diseases with the same therapy/Alzheimer's disease/Epilepsy/Network pharmacology/Molecular docking分类
医药卫生引用本文复制引用
黄千芊,黎咏麟,陈海生,高敏..基于网络药理学和分子对接技术分析黄连解毒汤异病同治阿尔茨海默病和癫痫的作用机制[J].新中医,2026,58(9):157-167,11.基金项目
广东省中医药局科研项目(20242006) （20242006）
