中国内镜杂志2026，Vol.32Issue(4)：20-27,8.DOI:10.12235/E20250463
维生素B12为佐剂的肋间神经阻滞对胸腔镜下肺部手术患者急慢性疼痛的干预效果研究
Study on the intervention effect of intercostal nerve block with vitamin B12 as an adjuvant on acute and chronic pain in patients undergoing thoracoscopic pulmonary surgery
摘要
Abstract
Objective To explore the intervention effect of intercostal nerve block(INB)with vitamin B12 as an adjuvant on acute and chronic pain in patients undergoing thoracoscopic pulmonary surgery.Methods 90 patients who underwent thoracoscopic pulmonary surgery in the hospital from June 2020 to June 2022 were selected.According to the different anesthetic enhancers used for INB after anesthesia induction,the patients were divided into group A,group B and group C,with 30 cases in each group.Group A was given intercostal INB(0.4％ropivacaine),group B was given intercostal INB(0.4％ropivacaine+dexamethasone)after conventional induction,and group C was given intercostal INB(0.4％ropivacaine+vitamin B12)after conventional induction.The postoperative pain degree,vital signs,perioperative sufentanil dosage and postoperative extubation time of the three groups were compared.Results The heart rate(HR),systolic blood pressure(SBP),diastolic blood pressure(DBP),and mean arterial pressure(MAP)at time points T1,T2,T3,T4,and T5 time points in group B and group C were significantly lower than those in group A,and the differences were statistically significant(P<0.05).The perioperative sufentanil dosage in group B and group C was significantly less than that in group A,and the postoperative extubation time was significantly shorter than that in group A.The differences were statistically significant(P<0.05).The visual analogue scale(VAS)scores of group B and group C at time points of T6,T7,T8,T9,T10,T11 and T12 were significantly lower than those of group A.The VAS scores of group C at time points T9,T10 and T11 were significantly lower than those of group B.The differences were statistically significant(P<0.05).The VAS scores of group B and group C at 1,3 and 6 months after surgery were significantly lower than those of group A,and the VAS scores of group C at 3 and 6 months after surgery were significantly lower than those of group B.The differences were statistically significant(P<0.05).Conclusion Vitamin B12 adjuvant INB is used in the intervention of thoracoscopic pulmonary surgery,with good clinical effects.It can relieve acute and chronic pain in patients,stabilize vital signs,reduce the dosage of sufentanil during the perioperative period,and shorten the extubation time after surgery.It is worthy of clinical application.关键词
维生素B12/肋间神经阻滞(INB)/胸腔镜下肺部手术/急慢性疼痛/干预效果Key words
vitamin B12/intercostal nerve block(INB)/thoracoscopic pulmonary surgery/acute and chronic pain/intervention effect分类
医药卫生引用本文复制引用
孙焕艳,汪敏,朱坤凌,张跃军..维生素B12为佐剂的肋间神经阻滞对胸腔镜下肺部手术患者急慢性疼痛的干预效果研究[J].中国内镜杂志,2026,32(4):20-27,8.基金项目
2022年度金华市第一批重大(重点)科技计划项目(2022-3-010) （重点）
