中国实用儿科杂志2026，Vol.41Issue(4)：316-322,7.DOI:10.19538/j.ek2026040610
出生早期肠道菌群定植在婴儿排便困难发生中的作用研究
Study on the role of intestinal flora colonization in early period of birth in the development of infant dyschezia
摘要
Abstract
Objective To investigate the influencing factors of early intestinal flora on the occurrence of infant dyschezia by analyzing clinical characteristics and sequencing meconium samples collected within 72h after birth,so as to provide new insights for early intestinal intervention.Methods Full-term neonates born at Shenzhen Maternity and Child Healthcare Hospital,Southern Medical University between January 2021 and April 2021 were enrolled.Clinical data were collected,and meconium samples were obtained within 72 h after birth.A questionnaire survey was completed by telephone follow-up at 3 months of age,and the infants suspected with dyschezia were recalled for hospital re-evaluation.Those meeting the Rome Ⅳcriteria were assigned to the infant dyschezia group,and the remaining infants were enrolled as the non-infant dyschezia group using propensity score matching at a ratio of 1∶4.Baseline clinical data were compared between the two groups,and analyze associated factors.In addition,another healthy control group were matched at a ratio of 1∶1 from the remaining cases using propensity score matching.The 16SrDNA sequencing was performed on the meconium samples of the two groups to compare differences in intestinal flora diversity,richness and community structure.Results The incidence of infant dyschezia was 4.3％.The prophylactic antibiotics use during the neonatal period was significantly different between the infant dyschezia group and the non-infant dyschezia group(P＜0.05).Vaginal delivery and prophylactic antibiotic use during the neonatal period were risk factors for infant dyschezia.There were no significant differences in the diversity and richness of intestinal flora between the infant dyschezia group and the healthy control group(P＞0.05).However,statistically significant differences were found in community structure at the phylum level of Spirochaetes and the genus levels of Bacteroides between the two groups(P＜0.05).Conclusion Vaginal delivery and prophylactic antibiotic use can increase the risk of developing infant dyschezia.No significant differences exist in the diversity and richness of early intestinal flora between the infants with dyschezia and the healthy infants in the postnatal period,whereas the relative abundance of Bacteroides at the genus level is significant higher than in healthy infants.关键词
婴儿排便困难/肠道菌群/抗生素/危险因素/胎粪/16SrDNA测序Key words
infant dyschezia/intestinal flora/antibiotics/risk factors/meconium/16SrDNA sequencing分类
医药卫生引用本文复制引用
曾凡菲,王媛媛,王丽婷,曾永梅,张纪泳,杨传忠,陈思齐,易琳,肖菲,李伟艳,丘晓颖..出生早期肠道菌群定植在婴儿排便困难发生中的作用研究[J].中国实用儿科杂志,2026,41(4):316-322,7.基金项目
深圳市科技计划资助项目(JCY20220530155208019) （JCY20220530155208019）
深圳市"医疗卫生三名工程"项目(SZSM202311021) （SZSM202311021）
