中国循证儿科杂志2026，Vol.21Issue(2)：81-86,6.DOI:10.3969/j.issn.1673-5501.2026.02.001
血液净化技术治疗儿童免疫性疾病的临床实践指南(2026年版)
Clinical practice guideline for the application of blood purification techniques in the management of immune-mediated diseases in pediatric patients(2026 Edition)
摘要
Abstract
Hemopurification demonstrates unique advantages in the treatment of immune-mediated diseases in children;however,there is a lack of systematic and comprehensive guidelines for pediatricians.The Extracorporeal Blood Purification Group and Hemodynamics Group,Pediatric Intensive Care Branch,Chinese Medical Doctor Association jointly organized domestic experts in pediatric critical care,nephrology,rheumatology,immunology,and evidence-based medicine.Following the specifications outlined in the World Health Organization(WHO)Handbook for Guideline Development and the Guiding Principles for Formulating/Revising Clinical Practice Guidelines in China(2022 Edition),a systematic literature search was conducted.The appraisal of guidelines for research and evaluation Ⅱ(AGREE Ⅱ)tool was used for systematic evaluation,multiple rounds of surveys were conducted to identify clinical questions,and grading of recommendations assessment,development and evaluation(GRADE)system was adopted to develop recommendation decision tables.Through multiple rounds of Delphi expert consultation and consensus meetings,recommendation statements were formulated and reported in accordance with the reporting items for practice guidelines in healthcare(RIGHT)standards.This guideline primarily addressed three clinical issues:therapeutic plasma exchange for immune-mediated diseases in children,immunoadsorption therapy for immune-mediated diseases in children,and hybrid hemopurification modalities for immune-mediated diseases in children.Based on 23 pieces of evidence,four recommendations were formulated,along with specific practical points.This guideline provides evidence-based rationale and operational standards for the rational application of hemopurification techniques in pediatric immune-mediated diseases,thereby further enhancing treatment safety and efficacy.关键词
血液净化/血浆置换/免疫吸附/儿童免疫性疾病/临床实践指南Key words
Blood purification/Plasma exchange/Immunoadsorption/Pediatric immune-mediated diseases/Clinical practice guideline引用本文复制引用
中国医师协会儿童重症医师分会血液净化学组,中国医师协会儿童重症医师分会血流动力学学组,王义,王卫凯..血液净化技术治疗儿童免疫性疾病的临床实践指南(2026年版)[J].中国循证儿科杂志,2026,21(2):81-86,6.基金项目
甘肃省科技重大专项:22ZD6FA034 （）
甘肃省联合科研基金项目:24JRRA940 （）
陕西省科技厅自然科学基金面上项目:2021JM-560 （）
